佛波酯刺激下中性粒细胞中超氧化物的释放及形态变化：钙结合蛋白抑制剂的拮抗作用
Release of superoxide and change in morphology by neutrophils in response to phorbol esters: antagonism by inhibitors of calcium-binding proteins.
作者信息
Robinson J M, Badwey J A, Karnovsky M L, Karnovsky M J
出版信息
J Cell Biol. 1985 Sep;101(3):1052-8. doi: 10.1083/jcb.101.3.1052.
Abstract
The ability of phorbol derivatives to function as stimulating agents for superoxide (O2-) release by guinea pig neutrophils has been evaluated and compared to the known ability of each compound to activate protein kinase C. Those that activate the kinase also stimulate O2- release, while those that are inactive with respect to the kinase have no effect on O2- release. The same correlation was observed with respect to the ability of phorbol esters to induce morphological changes in neutrophils, i.e., vesiculation and reduction in granule content. Certain phenothiazines and naphthalene sulfonamides that are known antagonists of calcium-binding proteins blocked both phorbol ester-induced O2- release and morphological changes in these cells.
摘要
已评估了佛波醇衍生物作为豚鼠中性粒细胞释放超氧化物（O2-）的刺激剂的能力，并将其与每种化合物激活蛋白激酶C的已知能力进行了比较。那些激活激酶的化合物也会刺激O2-的释放，而那些对激酶无活性的化合物对O2-的释放没有影响。在佛波醇酯诱导中性粒细胞形态变化的能力方面也观察到了相同的相关性，即形成囊泡和颗粒含量减少。某些已知为钙结合蛋白拮抗剂的吩噻嗪和萘磺酰胺可阻断佛波醇酯诱导的这些细胞中O2-的释放和形态变化。
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