Department of Gynecology and Obstetrics, Frauenklinik, Inselspital Bern, Switzerland.
Department of Gynecology and Obstetrics, Frauenklinik, Inselspital Bern, Switzerland.
Trends Endocrinol Metab. 2018 Aug;29(8):535-548. doi: 10.1016/j.tem.2018.05.006. Epub 2018 Jun 19.
Endometriosis is the growth of endometrial tissue outside the uterus and is characterized by progesterone resistance and changes in global and progesterone target gene expression. However, the mechanism behind this and whether it is innate, acquired, or present in both the eutopic and ectopic tissue in not always clear. We find large-scale gene expression studies in eutopic tissue, indicative of progesterone resistance, are often contradictory, potentially due to the dynamic nature of this tissue, whereas suppressed progesterone receptor expression is supported in ectopic but not eutopic tissue. This suggests more studies are required in eutopic tissue particularly, and that potentially the suppressed progesterone receptor (PR) expression is a consequence of the pathogenic process and exposure to the peritoneal environment.
子宫内膜异位症是指子宫内膜组织在子宫外生长，其特征是孕激素抵抗和整体及孕激素靶基因表达的改变。然而，其背后的机制尚不清楚，是先天的、后天的，还是在在位和异位组织中同时存在。我们发现，在位组织中大规模的基因表达研究表明孕激素抵抗往往是相互矛盾的，这可能是由于该组织的动态特性，而孕激素受体表达受抑制则在异位组织而非在位组织中得到支持。这表明需要对在位组织进行更多的研究，而且孕激素受体（PR）表达受抑制可能是发病过程和暴露于腹膜环境的结果。
