Wainberg M A, Portnoy J D, Clecner B, Hubschman S, Lagacé-Simard J, Rabinovitch N, Remer Z, Mendelson J
J Infect Dis. 1985 Sep;152(3):441-8. doi: 10.1093/infdis/152.3.441.
Herpes simplex viruses (HSV) are able to prevent the lectin-driven mitogenesis of coincubated human peripheral blood lymphocytes. This abrogation of responsiveness is independent of infection and can be obtained by using ultraviolet-inactivated as well as live virus particles. Lymphocytes from patients prone to frequent recurrences of HSV-induced lesions were more susceptible to inhibition of proliferative responsiveness than were cells from either individuals seronegative for HSV type 1 and HSV type 2 or individuals subject only to infrequent recurrences of HSV-induced disease. Lymphocytes from all patients tested were more susceptible to viral abrogation of mitogen responsiveness during preepisodic and acute as opposed to convalescent and postepisodic periods. When exogenous T cell growth factor was added to lymphoid cell cultures that had been coincubated with HSV, the cells were generally able to overcome the inhibition of responsiveness that would otherwise occur. However, this restoration of responsiveness occurred less efficiently in cells from patients with acute HSV-induced lesions and in cells from patients with frequent recurrences of lesions.
单纯疱疹病毒（HSV）能够阻止伴孵育的人外周血淋巴细胞由凝集素驱动的有丝分裂原性。这种反应性的消除与感染无关，使用紫外线灭活的病毒颗粒以及活病毒颗粒均可实现。与1型和2型HSV血清阴性的个体或仅偶尔复发HSV诱导疾病的个体的细胞相比，易频繁复发HSV诱导病变的患者的淋巴细胞对增殖反应性的抑制更敏感。与恢复期和发作后期相比，在发作前期和急性期，所有测试患者的淋巴细胞对病毒消除有丝分裂原反应性更敏感。当将外源性T细胞生长因子添加到与HSV伴孵育的淋巴细胞培养物中时，细胞通常能够克服否则会发生的反应性抑制。然而，在患有急性HSV诱导病变的患者的细胞和频繁复发病变的患者的细胞中，这种反应性的恢复效率较低。
