生长因子介导的毛细胞白血病肿瘤细胞增殖。
Growth factor-mediated tumor cell proliferation in hairy cell leukemia.
作者信息
Ford R J, Yoshimura L, Morgan J, Quesada J, Montagna R, Maizel A
出版信息
J Exp Med. 1985 Sep 1;162(3):1093-8. doi: 10.1084/jem.162.3.1093.
Abstract
Leukemic B cells from seven patients with hairy cell leukemia (HCL), six of which contained the Tac antigen, were assayed in vitro for growth factor-mediated cell proliferation. The HCL cells showed typical phenotypic profiles by monoclonal antibody analysis. The tumor cells, which do not grow spontaneously in vitro, were found to proliferate in all but one case in response to partially purified B cell growth factor (BCGF) without anti-mu or Sac activation. Recombinant interleukin 2 however produced only a marginal response and could not support leukemic cell growth in vitro. BCGF, however, did stimulate in vitro cell growth and supported the establishment of continuous (greater than 60 d in vitro) in four of the seven HCL cases.
摘要
对7例毛细胞白血病（HCL）患者的白血病B细胞进行了体外生长因子介导的细胞增殖检测，其中6例含有Tac抗原。通过单克隆抗体分析，HCL细胞显示出典型的表型特征。这些肿瘤细胞在体外不能自发生长，结果发现，除1例患者外，其余患者的肿瘤细胞在无抗μ或Sac激活的情况下，对部分纯化的B细胞生长因子（BCGF）有增殖反应。然而，重组白细胞介素2仅产生微弱反应，不能支持白血病细胞在体外生长。不过，BCGF确实能刺激体外细胞生长，并在7例HCL病例中的4例中支持建立连续（体外大于60天）培养。
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