两性霉素B和酮康唑对体外乙肝表面抗原产生的抑制作用。

Inhibition of in vitro HBsAg production by amphotericin B and ketoconazole.

作者信息

Pottage J C, Kessler H A

出版信息

J Med Virol. 1985 Jul;16(3):275-81. doi: 10.1002/jmv.1890160308.

Abstract

The effects of amphotericin B, ketoconazole, and adenine arabinoside on production of hepatitis B surface antigen (HBsAg) particles by the human hepatoma cell line PLC/PRF/5 were examined. In addition, the effects of these drugs on cellular protein synthesis were determined. These drugs caused a dose-dependent decrease in HBsAg production that was paralleled by a decrease in cellular protein synthesis. Ketoconazole was the most active of these drugs and the most specific, causing a 72% reduction in HBsAg production with only a 38% reduction in protein synthesis. These data suggest that further studies evaluating ketoconazole for the treatment of chronic hepatitis B virus infection in animals are warranted.

摘要

研究了两性霉素B、酮康唑和阿糖腺苷对人肝癌细胞系PLC/PRF/5产生乙型肝炎表面抗原（HBsAg）颗粒的影响。此外，还测定了这些药物对细胞蛋白质合成的影响。这些药物导致HBsAg产生呈剂量依赖性减少，同时细胞蛋白质合成也减少。酮康唑是这些药物中活性最高且最具特异性的，使HBsAg产生减少72%，而蛋白质合成仅减少38%。这些数据表明，有必要进一步开展研究，评估酮康唑在动物中治疗慢性乙型肝炎病毒感染的效果。