幽门螺杆菌与痴呆风险：一项基于人群的研究。
Helicobacter pylori and the risk of dementia: A population-based study.
机构信息
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
出版信息
Alzheimers Dement. 2018 Oct;14(10):1377-1382. doi: 10.1016/j.jalz.2018.05.005. Epub 2018 Jun 21.
INTRODUCTION
Helicobacter pylori infection might increase risk of dementia, but available evidence is inconsistent, and longitudinal studies are sparse. We investigated the association between H. pylori serology and dementia risk in a population-based cohort.
METHODS
Between 1997 and 2002, we measured H. pylori serum IgG titers in 4215 nondemented participants of the Rotterdam Study with a mean age of 69 years. We determined the association between H. pylori at baseline and dementia incidence until 2015, per natural log (U/mL) increase in titer, and for seropositive/seronegative, using Cox models adjusting for cohort, sex, age, education, and cardiovascular risk factors.
RESULTS
During a median follow-up of 13.3 years, 529 participants developed dementia, of which 463 had Alzheimer's disease. H. pylori was not associated with risk of dementia (hazard ratio [95% confidence interval] for antibody titer: 1.04 [0.90-1.21]; for seropositivity 1.03 [0.86-1.22]), or Alzheimer's disease.
DISCUSSION
In this community-dwelling population, H. pylori was not associated with dementia risk.
简介
幽门螺杆菌感染可能会增加痴呆的风险，但现有证据并不一致，且纵向研究较少。我们在一项基于人群的队列研究中调查了幽门螺杆菌血清学与痴呆风险之间的关系。
方法
1997 年至 2002 年间，我们对 Rotterdam 研究中的 4215 名无痴呆症的参与者进行了血清 IgG 抗体滴度的测量，他们的平均年龄为 69 岁。我们使用 Cox 模型，根据队列、性别、年龄、教育程度和心血管危险因素，对基线时的 H. pylori 与直至 2015 年的痴呆症发病率之间的关联进行了研究，还研究了血清抗体滴度每自然对数（U/mL）增加时以及血清阳性/阴性时的关联。
结果
在中位数为 13.3 年的随访期间，529 名参与者患上了痴呆症，其中 463 名患有阿尔茨海默病。H. pylori 与痴呆症风险（抗体滴度的风险比 [95%置信区间]：1.04 [0.90-1.21]；血清阳性率 1.03 [0.86-1.22]）或阿尔茨海默病无关。
讨论
在这个社区居民群体中，H. pylori 与痴呆风险无关。
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