Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110 USA; Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110 USA.
Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110 USA; Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110 USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110 USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 USA.
Curr Opin Immunol. 2018 Oct;54:7-12. doi: 10.1016/j.coi.2018.05.005. Epub 2018 Jun 21.
Atopic dermatitis (AD) is an inflammatory skin disease characterized by two primary features: relapsing skin lesions and chronic itch. Major advances in our understanding of type 2 immunity have led to new insights into the critical factors that promote the development and persistence of AD-associated skin inflammation. Although inflammation is strongly associated with the development of atopic itch, the precise mechanisms by which itch arises in AD are poorly understood. In this review, we highlight recent studies that have started to unveil how various proinflammatory factors released within the skin can elicit sensations of itch and discuss the therapeutic potential of targeting these neuroimmunologic processes.
特应性皮炎（AD）是一种炎症性皮肤病，其特征为两个主要特征：反复发作的皮肤损伤和慢性瘙痒。我们对 2 型免疫的理解的重大进展，使我们对促进 AD 相关皮肤炎症发展和持续存在的关键因素有了新的认识。尽管炎症与特应性瘙痒的发展密切相关，但 AD 中瘙痒产生的确切机制尚不清楚。在这篇综述中，我们重点介绍了最近的研究，这些研究开始揭示皮肤内释放的各种促炎因子如何引起瘙痒感，并讨论了针对这些神经免疫过程的治疗潜力。
