Miyawaki N, Matsumura Y, Ohno Y, Morimoto S
Life Sci. 1985 Sep 9;37(10):923-30. doi: 10.1016/0024-3205(85)90528-4.
The effects of vitamin E (VE)-deficiency on renin release by various agents were examined using rat kidney cortical slices. Isoproterenol and glucagon in the presence or absence of theophylline increased renin release in the control group, while their stimulatory effects were attenuated by VE-deficiency. These decreased responses of renin release to isoproterenol and glucagon due to VE-deficiency were restored to the control level by dietary supplementation of dl-alpha-tocopheryl acetate or N,N'-diphenyl-p-phenylenediamine. The stimulatory effect of dibutyryl cyclic AMP or theophylline on renin release was not affected by VE-deficiency. These results suggest that in case of VE-deficiency, the response of renin release to stimuli is decreased via cyclic-AMP production.
利用大鼠肾皮质切片研究了维生素E（VE）缺乏对各种药物引起的肾素释放的影响。在对照组中，异丙肾上腺素和胰高血糖素在有或没有茶碱存在的情况下均可增加肾素释放，而VE缺乏会减弱它们的刺激作用。通过饮食补充dl-α-生育酚醋酸酯或N，N'-二苯基对苯二胺，因VE缺乏导致的肾素释放对异丙肾上腺素和胰高血糖素反应的降低可恢复到对照水平。二丁酰环磷酸腺苷或茶碱对肾素释放的刺激作用不受VE缺乏的影响。这些结果表明，在VE缺乏的情况下，肾素释放对刺激的反应通过环磷酸腺苷的产生而降低。
