Raffay Thomas M, Walsh Michele C
Department of Pediatrics, University Hospitals Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, USA.
J Nat Sci. 2018;4(6).
Oxygen saturation targets in premature infants have been investigated in multiple international randomized controlled trials. Some trials have shown increased mortality with targeting lower (85% to 89%) compared to higher (91% to 95%) oxygen saturation ranges, while others have not. We will review the mortality outcomes of the largest multi-centered trials and a post hoc study that observed increased mortality at lower target ranges among small for gestational age infants. The planned Neonatal Oxygen Prospective Meta-analysis (NeOProM) collaborative will hopefully provide further insight into patient-specific risks, which include growth status.
多项国际随机对照试验对早产儿的氧饱和度目标进行了研究。一些试验表明，与较高（91%至95%）的氧饱和度范围相比，将氧饱和度目标设定为较低（85%至89%）会增加死亡率，而其他试验则未发现此现象。我们将回顾最大规模多中心试验的死亡率结果，以及一项事后分析研究，该研究观察到小于胎龄儿在较低目标范围时死亡率增加。计划中的新生儿氧前瞻性荟萃分析（NeOProM）合作项目有望进一步深入了解包括生长状况在内的患者特异性风险。
