2006 年至 2015 年韩国胆道癌的发病率和总生存率：利用国家健康信息数据库。
Incidence and Overall Survival of Biliary Tract Cancers in South Korea from 2006 to 2015: Using the National Health Information Database.
机构信息
Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
Department of Preventive Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
出版信息
Gut Liver. 2019 Jan 15;13(1):104-113. doi: 10.5009/gnl18105.
BACKGROUND/AIMS: There have been no nationwide studies to investigate the trends in incidence and 5-year survival rates of intra- and extrahepatic bile duct cancers and gallbladder cancer. Therefore, our study aimed to describe the incidence and 5-year survival rates of biliary tract cancers by subsites in South Korea.
METHODS
A total of 86,134 patients with biliary tract cancers were selected from the National Health Information Database. Age-standardized incidence rates and annual percentage changes were calculated. Lifetable methods and log-rank tests were used to determine the differences in survival rates. Cox-proportional hazard models were used to estimate the hazard ratio of the patients with biliary tract cancers.
RESULTS
The incidence rate of intrahepatic bile duct cancer decreased by 1.3% annually from 8.8 per 100,000 in 2006 to 7.8 per 100,000 in 2015. Extrahepatic bile duct cancer also showed a decreasing trend by 2.2% per year from 8.7 per 100,000 in 2006 to 6.7 per 100,000 in 2015. Gallbladder cancer showed the greatest decline, with an annual percentage change of 2.8% from 6.3 per 100,000 to 5.2 per 100,000 during the same period. The 5-year survival rates were 30.0% in gallbladder cancer, 27.8% in extrahepatic bile duct cancer, and 15.9% in intrahepatic bile duct cancer.
CONCLUSIONS
The overall incidence rates of intrahepatic and extrahepatic bile duct cancer and gallbladder cancer decreased from 2006 to 2015. Among biliary tract cancers, intrahepatic bile duct cancers exhibited the highest incidence rate and the worst survival rate.
背景/目的：目前还没有全国性的研究来调查肝内外胆管癌和胆囊癌的发病率和 5 年生存率趋势。因此，我们的研究旨在描述韩国胆道癌亚部位的发病率和 5 年生存率。
方法
从国家健康信息数据库中选择了 86134 名胆道癌患者。计算了年龄标准化发病率和年变化百分比。寿命表法和对数秩检验用于确定生存率的差异。Cox 比例风险模型用于估计胆道癌患者的风险比。
结果
2006 年至 2015 年，肝内胆管癌的发病率每年下降 1.3%，从每 10 万人 8.8 例降至每 10 万人 7.8 例。2006 年至 2015 年，肝外胆管癌的发病率也以每年 2.2%的速度下降，从每 10 万人 8.7 例降至每 10 万人 6.7 例。胆囊癌的下降幅度最大，同期从每 10 万人 6.3 例下降到每 10 万人 5.2 例，年变化百分比为 2.8%。胆囊癌的 5 年生存率为 30.0%，肝外胆管癌为 27.8%，肝内胆管癌为 15.9%。
结论
2006 年至 2015 年，肝内外胆管癌和胆囊癌的总发病率下降。在胆道癌中，肝内胆管癌的发病率最高，生存率最差。
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