0-3 Center for the at-Risk Infant, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini (LC), Italy.
Department of Newborn Medicine, Harvard Medical School, Boston, Massachusetts.
Pediatr Res. 2018 Jun;83(6):1104-1109. doi: 10.1038/pr.2018.25. Epub 2018 Jun 14.
BackgroundThe Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) is a standardized method for infant neurobehavioral assessment. Normative values are available for newborns, but the NNNS is not always feasible at birth. Unfortunately, 1-month NNNS normative data are lacking.AimsTo provide normative data for the NNNS examination at 1 month and to assess birth-to-one-month changes in NNNS summary scores.Study designThe NNNS was administered at birth and at 1 month within a longitudinal prospective study design.SubjectsA cohort of 99 clinically healthy full-term infants were recruited from a well-child nursery.Outcome measuresBirth-to-1-month NNNS variations were evaluated and the association of neonatal and sociodemographic variables with the rate of change of NNNS summary scores were investigated.Results and conclusionsNNNS scores from the 10th to the 90th percentile represent a range of normative performance at 1 month. A complex pattern of stability and change emerged comparing NNNS summary scores from birth to 1 month. Orienting, Regulation, and Quality of movements significantly increased, whereas Lethargy and Hypotonicity significantly decreased. Birth-to-1-month changes in NNNS performance suggest improvements in neurobehavioral organization. These data are useful for research purposes and for clinical evaluation of neurobehavioral performance in both healthy and at-risk 1-month-old infants.
新生儿重症监护病房网络神经行为量表（NNNS）是一种用于婴儿神经行为评估的标准化方法。有新生儿的正常值，但 NNNS 并不总是在出生时可行。不幸的是，1 个月的 NNNS 规范数据缺乏。
提供 1 个月时 NNNS 检查的规范数据，并评估从出生到 1 个月时 NNNS 综合评分的变化。
在一项纵向前瞻性研究设计中，在出生时和 1 个月时进行 NNNS 检查。
从一个健康儿童托儿所招募了 99 名临床健康的足月婴儿组成队列。
10 到 90 百分位的 NNNS 评分代表了 1 个月时的正常表现范围。与出生到 1 个月时的 NNNS 综合评分相比，出现了稳定和变化的复杂模式。定向、调节和运动质量显著增加，而嗜睡和张力减退显著减少。从出生到 1 个月时，NNNS 表现的变化表明神经行为组织的改善。这些数据可用于研究目的，以及用于评估健康和处于危险中的 1 个月大婴儿的神经行为表现。
