de Villiers J, Schaffner W, Tyndall C, Lupton S, Kamen R
Nature. 1984;312(5991):242-6. doi: 10.1038/312242a0.
Sequences which activate polyoma virus DNA replication are located within a region that also includes the transcriptional enhancer. We demonstrate a cis involvement of enhancers in DNA replication by showing that this region can be replaced by other enhancers, in a position- and orientation-independent manner, and that an immunoglobulin gene enhancer confers tissue-specific replicatory ability.
激活多瘤病毒DNA复制的序列位于一个也包含转录增强子的区域内。我们通过表明该区域可以以位置和方向独立的方式被其他增强子取代，以及免疫球蛋白基因增强子赋予组织特异性复制能力，证明了增强子在DNA复制中的顺式作用。
