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本文引用的文献

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Differential Diagnosis of Cavitary Lung Lesions.肺空洞性病变的鉴别诊断
J Belg Soc Radiol. 2016 Nov 19;100(1):100. doi: 10.5334/jbr-btr.1202.
2
Coccidioidomycosis and the skin: a comprehensive review.球孢子菌病与皮肤:全面综述
An Bras Dermatol. 2015 Sep-Oct;90(5):610-9. doi: 10.1590/abd1806-4841.20153805.
3
Increase in reported coccidioidomycosis--United States, 1998-2011.报告的球孢子菌病病例增加——美国,1998-2011 年。
MMWR Morb Mortal Wkly Rep. 2013 Mar 29;62(12):217-21.
4
The diagnosis of coccidioidomycosis.球孢子菌病的诊断。
F1000 Med Rep. 2010 Jan 18;2:2. doi: 10.3410/M2-2.
5
Cavitary pulmonary disease.空洞性肺疾病
Clin Microbiol Rev. 2008 Apr;21(2):305-33, table of contents. doi: 10.1128/CMR.00060-07.
6
Pulmonary coccidioidomycosis.肺球孢子菌病
Semin Respir Crit Care Med. 2008 Apr;29(2):166-73. doi: 10.1055/s-2008-1063855.
7
Reviews of anti-infective agents: posaconazole: a broad-spectrum triazole antifungal agent.抗微生物药物综述:泊沙康唑——一种广谱三唑类抗真菌药
Clin Infect Dis. 2007 Dec 15;45(12):1610-7. doi: 10.1086/523576.
8
Redefining the clinical spectrum of chronic pulmonary histoplasmosis: a retrospective case series of 46 patients.重新定义慢性肺组织胞浆菌病的临床谱:46例患者的回顾性病例系列研究
Medicine (Baltimore). 2007 Jul;86(4):252-258. doi: 10.1097/MD.0b013e318144b1d9.
9
Amphotericin B and coccidioidomycosis.两性霉素B与球孢子菌病
Ann N Y Acad Sci. 2007 Sep;1111:434-41. doi: 10.1196/annals.1406.019. Epub 2007 May 18.
10
Posaconazole (Noxafil): a new triazole antifungal agent.泊沙康唑(诺科飞):一种新型三唑类抗真菌药物。
Proc (Bayl Univ Med Cent). 2007 Apr;20(2):188-96. doi: 10.1080/08998280.2007.11928283.

1例采用泊沙康唑治疗成功的难治性肺球孢子菌病病例

A Case of Refractory Pulmonary Coccidioidomycosis Successfully Treated with Posaconazole Therapy.

作者信息

Patel R H, Pandya S, Nanjappa S, Greene J N

机构信息

Undergraduate Student, University of South Florida, USA.

Chief Infectious Diseases Fellow, University of South Florida, Morsani College of Medicine, USA.

出版信息

J Fam Med. 2017;4(6). doi: 10.26420/jfammed.2017.1130. Epub 2017 Nov 21.

DOI:10.26420/jfammed.2017.1130
PMID:29938709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6010061/
Abstract

Coccidioidomycosis is an endemic fungal infection caused by the inhalation of the spores of species. Patients with underlying immunosuppressive illness can contract chronic or disseminated disease which requires prolonged systemic therapy. Pulmonary coccidioidomycosis remains as an illusory and abstruse disease, with increased prevalence that poses as a challenge for clinicians in developing an effective strategy for treatment. Here, we report successful treatment of a refractory case of chronic relapsing pulmonary coccidioidomycosis in a 50-year old woman with a thin-walled cavitary lung lesion who was ultimately treated with posaconazole.

摘要

球孢子菌病是一种由吸入该菌种的孢子引起的地方性真菌感染。患有潜在免疫抑制疾病的患者可能会感染慢性或播散性疾病,这需要长期的全身治疗。肺球孢子菌病仍然是一种难以捉摸且晦涩难懂的疾病,其患病率不断上升,这对临床医生制定有效的治疗策略构成了挑战。在此,我们报告了一名50岁女性慢性复发性肺球孢子菌病难治性病例的成功治疗,该患者有薄壁空洞性肺部病变,最终接受泊沙康唑治疗。