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1例采用泊沙康唑治疗成功的难治性肺球孢子菌病病例

A Case of Refractory Pulmonary Coccidioidomycosis Successfully Treated with Posaconazole Therapy.

作者信息

Patel R H, Pandya S, Nanjappa S, Greene J N

机构信息

Undergraduate Student, University of South Florida, USA.

Chief Infectious Diseases Fellow, University of South Florida, Morsani College of Medicine, USA.

出版信息

J Fam Med. 2017;4(6). doi: 10.26420/jfammed.2017.1130. Epub 2017 Nov 21.

Abstract

Coccidioidomycosis is an endemic fungal infection caused by the inhalation of the spores of species. Patients with underlying immunosuppressive illness can contract chronic or disseminated disease which requires prolonged systemic therapy. Pulmonary coccidioidomycosis remains as an illusory and abstruse disease, with increased prevalence that poses as a challenge for clinicians in developing an effective strategy for treatment. Here, we report successful treatment of a refractory case of chronic relapsing pulmonary coccidioidomycosis in a 50-year old woman with a thin-walled cavitary lung lesion who was ultimately treated with posaconazole.

摘要

球孢子菌病是一种由吸入该菌种的孢子引起的地方性真菌感染。患有潜在免疫抑制疾病的患者可能会感染慢性或播散性疾病,这需要长期的全身治疗。肺球孢子菌病仍然是一种难以捉摸且晦涩难懂的疾病,其患病率不断上升,这对临床医生制定有效的治疗策略构成了挑战。在此,我们报告了一名50岁女性慢性复发性肺球孢子菌病难治性病例的成功治疗,该患者有薄壁空洞性肺部病变,最终接受泊沙康唑治疗。

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本文引用的文献

1
Differential Diagnosis of Cavitary Lung Lesions.肺空洞性病变的鉴别诊断
J Belg Soc Radiol. 2016 Nov 19;100(1):100. doi: 10.5334/jbr-btr.1202.
2
Coccidioidomycosis and the skin: a comprehensive review.球孢子菌病与皮肤:全面综述
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10
Posaconazole (Noxafil): a new triazole antifungal agent.泊沙康唑(诺科飞):一种新型三唑类抗真菌药物。
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