Lao Yi, Shi Jie, Wang Yalin, Ceschin Rafeal, Hwang Darryl, Nelson M D, Panigrahy Ashok, Leporé Natasha
Department of Radiology, Children's Hospital Los Angeles, Los Angeles CA, USA.
Department of Biomedical Engineering, University of Southern California, Los Angeles CA, USA.
Clin Image Based Proced. 2014;8361:1-9. doi: 10.1007/978-3-319-05666-1_1. Epub 2014 Mar 29.
Preterm neonates are at higher risk of neurocognitive and neurosensory abnormalities. While numerous studies have looked at the effect of prematurity on brain anatomy, none to date have attempted to understand the relative pose of subcortical structures and to assess its potential as a biomarker of abnormal growth. Here, we perform the first relative pose analysis on a point distribution model (PDM) of the thalamus between 17 preterm and 19 term-born healthy neonates. Initially, linear registration and constrained harmonic registration were computed to remove the irrelevant global pose information and obtain correspondence in vertices. All the parameters for the relative pose were then obtained through similarity transformation. Subsequently, all the pose parameters (scale, rotation and translation) were projected into a log-Euclidean space, where univariate and multivariate statistics were performed. Our method detected relative pose differences in the preterm birth for the left thalamus. Our results suggest that relative pose in subcortical structures is a useful indicator of brain injury, particularly along the anterior surface and the posterior surface. Our study supports the concept that there are regional thalamic asymmetries in the preterm that may be related to subtle white matter injury, have prognostic significance, or be related to preterm birth itself.
早产新生儿发生神经认知和神经感觉异常的风险更高。虽然众多研究关注了早产对脑解剖结构的影响，但迄今为止，尚无研究试图了解皮质下结构的相对姿态，并评估其作为异常生长生物标志物的潜力。在此，我们对17例早产和19例足月出生的健康新生儿的丘脑点分布模型（PDM）进行了首次相对姿态分析。首先，计算线性配准和约束调和配准，以去除无关的全局姿态信息并获得顶点对应关系。然后通过相似变换获得相对姿态的所有参数。随后，将所有姿态参数（比例、旋转和平移）投影到对数欧几里得空间中，在该空间中进行单变量和多变量统计。我们的方法检测到早产新生儿左丘脑的相对姿态差异。我们的结果表明，皮质下结构的相对姿态是脑损伤的有用指标，尤其是在前表面和后表面。我们的研究支持这样的概念，即早产中存在丘脑区域不对称，这可能与细微的白质损伤有关，具有预后意义，或与早产本身有关。
