限制性内切核酸酶诱导姐妹染色单体交换
Induction of sister-chromatid exchanges by restriction endonucleases.
作者信息
Natarajan A T, Mullenders L H, Meijers M, Mukherjee U
出版信息
Mutat Res. 1985 Sep;144(1):33-9. doi: 10.1016/0165-7992(85)90121-6.
PMID:2993874
Abstract
Restriction endonucleases Cfo 1, Pvu II, Sma I, Hpa II, Taq I and Hae III were tested for their ability to induce SCEs in CHO cells. The results indicate that the DNA double-strand breaks induced during S-phase by these enzymes lead to an increase in the frequencies of SCEs.
摘要
对限制性内切酶Cfo 1、Pvu II、Sma I、Hpa II、Taq I和Hae III诱导中国仓鼠卵巢（CHO）细胞姐妹染色单体交换（SCE）的能力进行了测试。结果表明，这些酶在S期诱导的DNA双链断裂导致SCE频率增加。
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