Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences , Wuhan University , Wuhan , 430072 , China.
ACS Appl Mater Interfaces. 2019 Apr 17;11(15):13859-13873. doi: 10.1021/acsami.8b06175. Epub 2018 Jun 25.
Re-engineering cellular components and biological processes has received great interest and promised compelling advantages in applications ranging from basic cell biology to biomedicine. With the advent of DNA nanotechnology, the programmable self-assembly ability makes DNA an appealing candidate for rational design of artificial components with different structures and functions. This Forum Article summarizes recent developments of DNA nanotechnology in mimicking the structures and functions of existing cellular components. We highlight key successes in the achievements of DNA-based biomimetic membrane proteins and discuss the assembly behavior of these artificial proteins. Then, we focus on the construction of higher-order structures by DNA nanotechnology to recreate cell-like structures. Finally, we explore the current challenges and speculate on future directions of DNA nanotechnology in biomimetics.
对细胞成分和生物过程进行再工程化引起了广泛关注，并有望在从基础细胞生物学到生物医学的各个领域带来引人注目的优势。随着 DNA 纳米技术的出现，可编程的自组装能力使 DNA 成为合理设计具有不同结构和功能的人工组件的有吸引力的候选者。本文总结了 DNA 纳米技术在模拟现有细胞成分的结构和功能方面的最新进展。我们重点介绍了基于 DNA 的仿生膜蛋白在实现方面的关键成功，并讨论了这些人工蛋白的组装行为。然后，我们专注于通过 DNA 纳米技术构建高级结构以重现类细胞结构。最后，我们探讨了当前的挑战，并对 DNA 纳米技术在仿生学中的未来发展方向进行了推测。
