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本文引用的文献

1
Efficacy and Safety of First-line Avelumab Treatment in Patients With Stage IV Metastatic Merkel Cell Carcinoma: A Preplanned Interim Analysis of a Clinical Trial.一线阿维鲁单抗治疗 IV 期转移性 Merkel 细胞癌患者的疗效和安全性：一项临床试验的预先计划的中期分析。
JAMA Oncol. 2018 Sep 1;4(9):e180077. doi: 10.1001/jamaoncol.2018.0077. Epub 2018 Sep 13.
2
Avelumab in metastatic urothelial carcinoma after platinum failure (JAVELIN Solid Tumor): pooled results from two expansion cohorts of an open-label, phase 1 trial.阿维鲁单抗治疗铂类治疗失败后的转移性尿路上皮癌（JAVELIN Solid Tumor）：一项开放标签、1 期试验两个扩展队列的汇总结果。
Lancet Oncol. 2018 Jan;19(1):51-64. doi: 10.1016/S1470-2045(17)30900-2. Epub 2017 Dec 5.
3
The FDA Oncology Center of Excellence and precision medicine.美国食品和药物管理局肿瘤卓越中心与精准医学
Exp Biol Med (Maywood). 2018 Feb;243(3):308-312. doi: 10.1177/1535370217740861. Epub 2017 Nov 6.
4
Durvalumab after Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer.Durvalumab 用于 III 期非小细胞肺癌放化疗后的治疗。
N Engl J Med. 2017 Nov 16;377(20):1919-1929. doi: 10.1056/NEJMoa1709937. Epub 2017 Sep 8.
5
Oncology Drug Approvals: Evaluating Endpoints and Evidence in an Era of Breakthrough Therapies.肿瘤药物审批：在突破性治疗时代评估终点和证据。
Oncologist. 2017 Jul;22(7):762-767. doi: 10.1634/theoncologist.2017-0152. Epub 2017 Jun 2.
6
ADCC employing an NK cell line (haNK) expressing the high affinity CD16 allele with avelumab, an anti-PD-L1 antibody.采用表达高亲和力CD16等位基因的NK细胞系（haNK）与抗PD-L1抗体阿维鲁单抗进行抗体依赖的细胞介导的细胞毒性作用（ADCC）。
Int J Cancer. 2017 Aug 1;141(3):583-593. doi: 10.1002/ijc.30767. Epub 2017 May 19.
7
Enhanced antitumor effects by combining an IL-12/anti-DNA fusion protein with avelumab, an anti-PD-L1 antibody.通过将白细胞介素-12/抗DNA融合蛋白与抗PD-L1抗体阿维鲁单抗联合使用增强抗肿瘤效果。
Oncotarget. 2017 Mar 28;8(13):20558-20571. doi: 10.18632/oncotarget.16137.
8
Avelumab: clinical trial innovation and collaboration to advance anti-PD-L1 immunotherapy.阿维鲁单抗：推进抗程序性死亡配体1免疫疗法的临床试验创新与合作
Ann Oncol. 2017 Jul 1;28(7):1658-1666. doi: 10.1093/annonc/mdx170.
9
Avelumab, an Anti-Programmed Death-Ligand 1 Antibody, In Patients With Refractory Metastatic Urothelial Carcinoma: Results From a Multicenter, Phase Ib Study.阿维鲁单抗，一种抗程序性死亡配体1抗体，用于难治性转移性尿路上皮癌患者：一项多中心1b期研究的结果
J Clin Oncol. 2017 Jul 1;35(19):2117-2124. doi: 10.1200/JCO.2016.71.6795. Epub 2017 Apr 4.
10
Avelumab for patients with previously treated metastatic or recurrent non-small-cell lung cancer (JAVELIN Solid Tumor): dose-expansion cohort of a multicentre, open-label, phase 1b trial.阿维鲁单抗用于既往接受过治疗的转移性或复发性非小细胞肺癌患者（JAVELIN实体瘤研究）：一项多中心、开放标签的1b期试验的剂量扩展队列研究
Lancet Oncol. 2017 May;18(5):599-610. doi: 10.1016/S1470-2045(17)30240-1. Epub 2017 Mar 31.

Avelumab: is it time to get excited?

作者信息

Marciscano Ariel E, Gulley James L, Kaufman Howard L

机构信息

a Genitourinary Malignancies Branch , Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.

b Department of Medicine , Replimune Group Inc , Woburn , MA , USA.

出版信息

Expert Rev Anticancer Ther. 2018 Sep;18(9):815-821. doi: 10.1080/14737140.2018.1493380. Epub 2018 Jul 2.

DOI:10.1080/14737140.2018.1493380
PMID:29939083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8232371/
Abstract
摘要