Vasar E E, Ryago L K
Neurosci Behav Physiol. 1985 May-Jun;15(3):232-6. doi: 10.1007/BF01182992.
The behavioral and biochemical effects of intracerebroventricular administration of cholecystokinin were investigated in experiments on male Wistar rats. Cholecystokinin induced specific dose-dependent changes in the behavior of the animals. At low doses the inhibiting influence on behavior predominated; at high doses stereo-typed behavior, shaking of the head and increased reactivity to pain stimuli were observed. Cholecystokinin appreciably inhibited the circulation of serotonin and dopamine in the brain structures in comparison with physiological saline solution. Administration of cholecystokinin against a background of phenamine and 5-hydroxy-tryptophan briefly entirely inhibited the behavioral effects induced by these substances. On the basis of the data obtained it can be assumed that cholecystokinin is an endogenous modulator of the activity of the monoaminergic systems of the brain.
在雄性Wistar大鼠实验中，研究了脑室内注射胆囊收缩素的行为和生化效应。胆囊收缩素诱导动物行为发生特定的剂量依赖性变化。低剂量时，对行为的抑制作用占主导；高剂量时，观察到刻板行为、摇头以及对疼痛刺激的反应性增加。与生理盐水相比，胆囊收缩素明显抑制了脑结构中血清素和多巴胺的循环。在苯丙胺和5-羟色氨酸背景下注射胆囊收缩素，可短暂完全抑制这些物质诱导的行为效应。根据所得数据可以推测，胆囊收缩素是脑单胺能系统活性的内源性调节剂。
