Obstet Gynecol. 2018 Jul;132(1):e18-e34. doi: 10.1097/AOG.0000000000002703.
Inherited thrombophilias are associated with an increased risk of venous thromboembolism and have been linked to adverse outcomes in pregnancy. However, there is limited evidence to guide screening for and management of these conditions in pregnancy. The purpose of this document is to review common thrombophilias and their association with maternal venous thromboembolism risk and adverse pregnancy outcomes, indications for screening to detect these conditions, and management options in pregnancy. This Practice Bulletin has been revised to provide additional information on recommendations for candidates for thrombophilia evaluation, updated consensus guidelines regarding the need for prophylaxis in women with an inherited thrombophilia during pregnancy and the postpartum period, and discussion of new published consensus guidelines from the Society for Obstetric Anesthesia and Perinatology addressing thromboprophylaxis and neuraxial anesthetic considerations in the obstetric population.
遗传性血栓形成倾向与静脉血栓栓塞风险增加相关，并与妊娠不良结局相关。然而，目前仅有有限的证据可以指导妊娠期筛查和处理这些疾病。本文件旨在回顾常见的血栓形成倾向及其与母体静脉血栓栓塞风险和妊娠不良结局的关联、筛查这些疾病的指征，以及妊娠期的管理选择。本实践指南已修订，以提供有关血栓形成倾向评估候选者的建议、关于妊娠和产后期间遗传性血栓形成倾向女性预防的最新共识指南，以及讨论产科人群中血栓预防和神经轴麻醉注意事项的新发布的产科麻醉和围产医学学会共识指南。
