Comprehensive Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China.
Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China.
Clin Chim Acta. 2018 Oct;485:50-59. doi: 10.1016/j.cca.2018.06.030. Epub 2018 Jun 22.
Accumulating studies have demonstrated that Krüppel-like factor 4 (KLF4) can act as a tumor suppressor or oncogene in the carcinogenesis of diverse cancers. The prognostic value of KLF4 in various human solid cancers remains controversial. Thus, the present meta-analysis was conducted to evaluate the prognostic value of KLF4 in solid tumors.
Eligible literature was retrieved by searching the PubMed, Embase, and Cochrane Library. Combined hazard ratios (HRs) for overall survival (OS) and disease-free survival (DFS) were assessed using fixed-effects and random-effects models. Meta-regression and subgroup analyses were performed to identify the source of heterogeneity. In addition, publication bias was assessed using Begg's funnel plot and Egger's regression asymmetry test.
The 22 eligible studies finally enrolled a total of 2988 patients to assess the prognostic value of KLF4 in solid tumors. Low KLF4 expression was clearly related to worse OS (HR = 1.71, 95% confidence interval [CI] = 1.30-2.24, P < 0.001) and DFS (HR = 1.74, 95% CI = 1.34-2.26, P < 0.001), indicating that low KLF4 expression could be an independent prognostic factor for poor survival in solid cancers.
KLF4 might be a potential marker to predict prognosis in solid cancer patients.
越来越多的研究表明，Krüppel 样因子 4（KLF4）在多种癌症的发生发展过程中既可以作为抑癌基因，也可以作为癌基因。KLF4 在各种实体瘤中的预后价值仍存在争议。因此，本荟萃分析旨在评估 KLF4 在实体瘤中的预后价值。
通过检索 PubMed、Embase 和 Cochrane Library 数据库，筛选出符合条件的文献。使用固定效应模型和随机效应模型评估总生存（OS）和无病生存（DFS）的合并风险比（HR）。采用Meta 回归和亚组分析来确定异质性的来源。此外，还使用 Begg 漏斗图和 Egger 回归不对称检验评估发表偏倚。
最终纳入的 22 项研究共纳入了 2988 例患者，以评估 KLF4 在实体瘤中的预后价值。低 KLF4 表达与较差的 OS（HR=1.71，95%置信区间[CI]=1.30-2.24，P<0.001）和 DFS（HR=1.74，95%CI=1.34-2.26，P<0.001）显著相关，表明低 KLF4 表达可能是实体癌患者生存不良的独立预后因素。
KLF4 可能是预测实体癌患者预后的潜在标志物。
