University of Iceland, School of Medicine, Reykjavik, Iceland.
Sahlgrenska University Hospital, Gothenburg, Sweden.
Neuroepidemiology. 2018;51(1-2):50-56. doi: 10.1159/000489472. Epub 2018 Jun 25.
In this study, we examined multiple sclerosis (MS) point prevalence in the well-defined island population of Iceland.
This study included all registered residents of Iceland with MS on the prevalence day, December 31, 2007. All included patients met at least one of the following criteria: McDonald criteria; Poser criteria for clinically definite MS, laboratory-supported definite MS, clinically probable MS; or criteria for primary progressive MS. The patients' medical records were reviewed, including all available MRI data acquired prior to the prevalence day.
We identified 526 patients, of whom 73% (382) were women. The crude point prevalence of MS was 167.1 per 100,000 population on the prevalence day. With age adjustment made to the 2000 U.S. population, the prevalence was 166.5 per 100,000 population. The mean patient age on the prevalence day was 47 years(range 13-89) for both men and women. The mean age at diagnosis was 36 years (range 13-77): 35 years for women and 36 years for men.
MS prevalence was high in Iceland compared to the prevalence mentioned in reports from most of the world, and was similar to prevalence rates in other Nordic countries.
在这项研究中，我们检查了冰岛这个明确界定的岛屿人群中的多发性硬化症（MS）现患率。
本研究包括在 2007 年 12 月 31 日现患日登记的所有患有 MS 的冰岛注册居民。所有纳入的患者均符合以下标准之一：麦克唐纳标准；Poser 标准的临床确诊 MS、实验室支持的确诊 MS、临床可能 MS；或原发性进展性 MS 的标准。对患者的病历进行了回顾，包括在现患日之前获得的所有现有 MRI 数据。
我们确定了 526 名患者，其中 73%（382 名）为女性。现患日 MS 的粗现患率为每 100,000 人口 167.1 例。根据 2000 年美国人口进行年龄调整后，现患率为每 100,000 人口 166.5 例。现患日男女患者的平均年龄分别为 47 岁（范围 13-89 岁）。诊断时的平均年龄为 36 岁（范围 13-77 岁）：女性为 35 岁，男性为 36 岁。
与世界大部分地区的报告中提到的发病率相比，冰岛的 MS 发病率较高，与其他北欧国家的发病率相似。
