Hernández Miguel Angel
Service of Neurology, Hospital Ntra. Sra. de Candelaria, C/Rosario s/n, 38010 Santa Cruz de Tenerife, Canary Islands, Spain.
J Neurol. 2002 Oct;249(10):1378-81. doi: 10.1007/s00415-002-0841-y.
To determine the prevalence of multiple sclerosis (MS) on the Island of La Palma, Canary Islands, Spain.
A population-based transverse study was carried out on the Island of La Palma (population: 81,507), from 1995 to 1998. The 15 December 1998 was established as prevalence day. Sources of information were periodically obtained from case records from public primary care centres, private hospitals, private centres, magnetic resonance units and others. In accordance with the Poser criteria all cases of definite or probable MS were included.
34 cases of MS were found on prevalence day (9 male and 25 female): 32 cases were clinically definite and 2 were clinically probable MS. Crude prevalence was 42/100,000. Incidence during time of study was 2.25/100,000.
The island of La Palma could be considered as an area of medium-high risk, the risk being higher than that expected because of the geographical latitude of the island. This study confirms the hypothesis of the high prevalence of MS in Spain. We have not found significant clinical differences in MS patients from those in other studies.
确定西班牙加那利群岛拉帕尔马岛多发性硬化症（MS）的患病率。
1995年至1998年在拉帕尔马岛（人口：81,507）开展了一项基于人群的横断面研究。将1998年12月15日定为患病率调查日。信息来源定期取自公立初级保健中心、私立医院、私立机构、磁共振检查单位及其他机构的病例记录。根据波泽标准纳入所有确诊或可能为MS的病例。
在患病率调查日发现34例MS病例（9例男性，25例女性）：32例为临床确诊病例，2例为临床可能病例。粗患病率为42/100,000。研究期间的发病率为2.25/100,000。
拉帕尔马岛可被视为中高风险地区，该风险高于因该岛地理纬度所预期的风险。本研究证实了西班牙MS高患病率的假说。我们未发现MS患者与其他研究中的患者存在显著临床差异。
