Zhang Hongliang, Leng Chaoliang, Tian Zhijun, Liu Chunxiao, Chen Jiazeng, Bai Yun, Li Zhen, Xiang Lirun, Zhai Hongyue, Wang Qian, Peng Jinmei, An Tongqing, Kan Yunchao, Yao Lunguang, Yang Xufu, Cai Xuehui, Tong Guangzhi
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, China.
Henan Key Laboratory of Insect Biology in Funiu Mountain, Henan Provincial Engineering Laboratory of Insects Bio-reactor, China-UK-NYNU-RRes Joint Laboratory of Insect Biology, Nanyang Normal University, Nanyang, 473061, China.
BMC Vet Res. 2018 Jun 25;14(1):204. doi: 10.1186/s12917-018-1504-2.
Classical swine fever (CSF) is one of the most devastating and highly contagious viral diseases in the world. Since late 2014, outbreaks of a new sub-genotype 2.1d CSF virus (CSFV) had caused substantial economic losses in numbers of C-strain vaccinated swine farms in China. The objective of the present study was to explore the genomic characteristics and pathogenicity of the newly emerged CSFV isolates in China during 2014-2015.
All the new 8 CSFV isolates belonged to genetic sub-genotype 2.1d. Some genomic variations or deletions were found in the UTRs and E2 of these new isolates. In addition, the pathogenicity of HLJ1 was less than Shimen, suggesting the HLJ1 of sub-genotype 2.1d may be a moderated pathogenic isolate and the C-strain vaccine can supply complete protection.
The new CSFV isolates with unique genomic characteristics and moderate pathogenicity can be epidemic in many large-scale C-strain vaccinated swine farms. This study provides the information should be merited special attention on establishing prevention and control policies for CSF.
经典猪瘟（CSF）是世界上最具毁灭性和高度传染性的病毒性疾病之一。自2014年末以来，新的2.1d亚型猪瘟病毒（CSFV）的爆发在中国多个接种C株疫苗的猪场造成了巨大经济损失。本研究的目的是探索2014 - 2015年期间中国新出现的CSFV分离株的基因组特征和致病性。
所有8株新的CSFV分离株均属于基因2.1d亚型。在这些新分离株的非翻译区（UTR）和E2区发现了一些基因组变异或缺失。此外，HLJ1的致病性低于石门株，表明2.1d亚型的HLJ1可能是一种致病性较弱的分离株，C株疫苗可提供完全保护。
具有独特基因组特征和中等致病性的新CSFV分离株可在许多大规模接种C株疫苗的猪场流行。本研究提供的信息在制定CSF防控政策时应予以特别关注。
