2014 - 2015年中国新出现的经典猪瘟病毒分离株的特征分析
Characterisation of Newly Emerged Isolates of Classical Swine Fever Virus in China, 2014-2015.
作者信息
Leng Chaoliang, Zhang Hongliang, Kan Yunchao, Yao Lunguang, Li Mingliang, Zhai Hongyue, Li Zhen, Liu Chunxiao, Shi Hongfei, Ji Jun, Qiu Reng, Tian Zhijun
机构信息
Henan Key Laboratory of Insect Biology in Funiu Mountain, Henan Provincial Engineering Laboratory of Insects Bio-reactor, China-UK-NYNU-RRes Joint Laboratory of Insect Biology, Nanyang Normal University, Nanyang 473061, China.
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
出版信息
J Vet Res. 2017 Apr 4;61(1):1-9. doi: 10.1515/jvetres-2017-0001. eCollection 2017 Mar.
INTRODUCTION
In 2014-2015, the epidemic of classical swine fever (CSF) occurred in many large-scale pig farms in different provinces of China, and a subgenotype 2.1d of CSF virus (CSFV) was newly identified.
MATERIAL AND METHODS
The phylogenetic relationship, genetic diversity, and epidemic status of the 2014-2015 CSFV isolates, 18 new CSFV isolates collected in 2015, and 43 other strains isolated in 2014-2015 were fully analysed, together with 163 CSFV reference isolates.
RESULTS
Fifty-two 2014-2015 isolates belonged to subgenotype 2.1d and nine other isolates belonged to subgenotype 2.1b. The two subgenotype isolates showed unique molecular characteristics. Furthermore, the 2.1d isolates were found to possibly diverge from 2.1b isolates.
CONCLUSION
This study suggests that the Chinese CSFVs will remain pandemic.
引言
2014 - 2015年，中国不同省份的许多大型养猪场发生了经典猪瘟（CSF）疫情，并且新鉴定出一种猪瘟病毒（CSFV）的2.1d亚基因型。
材料与方法
对2014 - 2015年的CSFV分离株、2015年收集的18株新的CSFV分离株以及2014 - 2015年分离的其他43株菌株，连同163株CSFV参考分离株的系统发育关系、遗传多样性和流行状况进行了全面分析。
结果
52株2014 - 2015年的分离株属于2.1d亚基因型，另外9株分离株属于2.1b亚基因型。这两种亚基因型分离株表现出独特的分子特征。此外，发现2.1d分离株可能与2.1b分离株有所分化。
结论
本研究表明中国的CSFV将继续流行。
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