Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
China-ASEAN College of Marine Sciences, Xiamen University Malaysia, Jalan Sunsuria, Bandar Sunsuria, 43900, Sepang, Selangor, Malaysia.
BMC Complement Altern Med. 2018 Jun 25;18(1):195. doi: 10.1186/s12906-018-2199-4.
Coconut water has been commonly consumed as a beverage for its multiple health benefits while vinegar has been used as common seasoning and a traditional Chinese medicine. The present study investigates the potential of coconut water vinegar in promoting recovery on acetaminophen induced liver damage.
Mice were injected with 250 mg/kg body weight acetaminophen for 7 days and were treated with distilled water (untreated), Silybin (positive control) and coconut water vinegar (0.08 mL/kg and 2 mL/kg body weight). Level of oxidation stress and inflammation among treated and untreated mice were compared.
Untreated mice oral administrated with acetaminophen were observed with elevation of serum liver profiles, liver histological changes, high level of cytochrome P450 2E1, reduced level of liver antioxidant and increased level of inflammatory related markers indicating liver damage. On the other hand, acetaminophen challenged mice treated with 14 days of coconut water vinegar were recorded with reduction of serum liver profiles, improved liver histology, restored liver antioxidant, reduction of liver inflammation and decreased level of liver cytochrome P450 2E1 in dosage dependent level.
Coconut water vinegar has helped to attenuate acetaminophen-induced liver damage by restoring antioxidant activity and suppression of inflammation.
椰子水因其多种健康益处而被广泛作为饮料消费，而醋则被用作常见的调味料和传统中药。本研究调查了椰子水醋在促进对乙酰氨基酚诱导的肝损伤恢复方面的潜力。
将 250mg/kg 体重的对乙酰氨基酚注射到小鼠体内，连续 7 天，并用蒸馏水（未处理）、水飞蓟素（阳性对照）和椰子水醋（0.08mL/kg 和 2mL/kg 体重）进行处理。比较处理和未处理小鼠的氧化应激和炎症水平。
未处理的小鼠口服给予对乙酰氨基酚后，血清肝谱升高，肝组织学变化，细胞色素 P450 2E1 水平升高，肝抗氧化水平降低，炎症相关标志物水平升高，表明肝损伤。另一方面，用椰子水醋处理 14 天的乙酰氨基酚挑战小鼠，其血清肝谱降低，肝组织学改善，肝抗氧化恢复，肝炎症减少，肝细胞色素 P450 2E1 水平降低，呈剂量依赖性。
椰子水醋通过恢复抗氧化活性和抑制炎症，有助于减轻对乙酰氨基酚引起的肝损伤。
