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肺癌细胞培养中载有阿霉素的提取物衍生金纳米颗粒的合成与毒性评估

Synthesis and toxicity assessment of extract-derived gold nanoparticles loaded with doxorubicin in lung cancer cell cultures.

作者信息

Trejo-Teniente Isaí, Jaramillo-Loranca Blanca Estela, Vargas-Hernández Genaro, Villanueva-Ibáñez Maricela, Tovar-Jiménez Xochitl, Olvera-Venegas Patricia Nayeli, Tapia-Ramírez José

机构信息

Laboratory of Nanotechnology, New Materials and Systems for Health, Industry and Alternative Energies, Universidad Politécnica de Pachuca, Zempoala, Hidalgo, Mexico.

Laboratory of Bioactive Compounds, Universidad Politécnica de Pachuca, Zempoala, Hidalgo, Mexico.

出版信息

Front Bioeng Biotechnol. 2024 Apr 26;12:1378601. doi: 10.3389/fbioe.2024.1378601. eCollection 2024.

DOI:10.3389/fbioe.2024.1378601
PMID:38737534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11082400/
Abstract

Cancer is the second leading cause of death worldwide, despite the many treatments available, cancer patients face side effects that reduce their quality of life. Therefore, there is a need to develop novel strategies to increase the efficacy of treatments. In this study, gold nanoparticles obtained by green synthesis with green bean extract were loaded with Doxorubicin, (a highly effective but non-specific drug) by direct interaction and using commercial organic ligands that allow colloidal dispersion at physiological and tumor pH. Conjugation of these components resulted in stable nanohybrids at physiological pH and a tumor pH release dependent, with a particle size less than 40 nm despite having the ligands and Doxorubicin loaded on their surface, which gave them greater specificity and cytotoxicity in H69 tumor cells.

摘要

癌症是全球第二大死因，尽管有多种治疗方法，但癌症患者仍面临副作用，这些副作用会降低他们的生活质量。因此，需要开发新的策略来提高治疗效果。在本研究中，通过与绿豆提取物进行绿色合成获得的金纳米颗粒，通过直接相互作用并使用能够在生理和肿瘤pH值下实现胶体分散的商业有机配体，负载了阿霉素（一种高效但非特异性的药物）。这些成分的结合在生理pH值下产生了稳定的纳米杂化物，并且具有肿瘤pH值依赖性释放，尽管其表面负载有配体和阿霉素，但其粒径小于40纳米，这使得它们在H69肿瘤细胞中具有更高的特异性和细胞毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/2f4112f0c07d/fbioe-12-1378601-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/4c4cc2e888e7/fbioe-12-1378601-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/859fd1ae0ef2/fbioe-12-1378601-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/7e7c4c0d1b91/fbioe-12-1378601-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/48bc65e66cf8/fbioe-12-1378601-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/e3cbbbf37827/fbioe-12-1378601-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/ee0c91b24ae7/fbioe-12-1378601-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/f718c27bb20d/fbioe-12-1378601-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/372037577d92/fbioe-12-1378601-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/2f4112f0c07d/fbioe-12-1378601-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/4c4cc2e888e7/fbioe-12-1378601-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/859fd1ae0ef2/fbioe-12-1378601-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/7e7c4c0d1b91/fbioe-12-1378601-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/48bc65e66cf8/fbioe-12-1378601-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/e3cbbbf37827/fbioe-12-1378601-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/ee0c91b24ae7/fbioe-12-1378601-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/f718c27bb20d/fbioe-12-1378601-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/372037577d92/fbioe-12-1378601-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/2f4112f0c07d/fbioe-12-1378601-g009.jpg

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Carbohydr Polym. 2020 Feb 1;229:115511. doi: 10.1016/j.carbpol.2019.115511. Epub 2019 Oct 22.