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核心技术专利：CN118964589B侵权必究
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Synthesis and toxicity assessment of extract-derived gold nanoparticles loaded with doxorubicin in lung cancer cell cultures.

作者信息

Trejo-Teniente Isaí, Jaramillo-Loranca Blanca Estela, Vargas-Hernández Genaro, Villanueva-Ibáñez Maricela, Tovar-Jiménez Xochitl, Olvera-Venegas Patricia Nayeli, Tapia-Ramírez José

机构信息

Laboratory of Nanotechnology, New Materials and Systems for Health, Industry and Alternative Energies, Universidad Politécnica de Pachuca, Zempoala, Hidalgo, Mexico.

Laboratory of Bioactive Compounds, Universidad Politécnica de Pachuca, Zempoala, Hidalgo, Mexico.

出版信息

Front Bioeng Biotechnol. 2024 Apr 26;12:1378601. doi: 10.3389/fbioe.2024.1378601. eCollection 2024.

DOI:10.3389/fbioe.2024.1378601
PMID:38737534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11082400/
Abstract

Cancer is the second leading cause of death worldwide, despite the many treatments available, cancer patients face side effects that reduce their quality of life. Therefore, there is a need to develop novel strategies to increase the efficacy of treatments. In this study, gold nanoparticles obtained by green synthesis with green bean extract were loaded with Doxorubicin, (a highly effective but non-specific drug) by direct interaction and using commercial organic ligands that allow colloidal dispersion at physiological and tumor pH. Conjugation of these components resulted in stable nanohybrids at physiological pH and a tumor pH release dependent, with a particle size less than 40 nm despite having the ligands and Doxorubicin loaded on their surface, which gave them greater specificity and cytotoxicity in H69 tumor cells.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/2f4112f0c07d/fbioe-12-1378601-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/4c4cc2e888e7/fbioe-12-1378601-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/859fd1ae0ef2/fbioe-12-1378601-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/7e7c4c0d1b91/fbioe-12-1378601-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/48bc65e66cf8/fbioe-12-1378601-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/e3cbbbf37827/fbioe-12-1378601-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/ee0c91b24ae7/fbioe-12-1378601-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/f718c27bb20d/fbioe-12-1378601-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/372037577d92/fbioe-12-1378601-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/2f4112f0c07d/fbioe-12-1378601-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/4c4cc2e888e7/fbioe-12-1378601-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/859fd1ae0ef2/fbioe-12-1378601-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/7e7c4c0d1b91/fbioe-12-1378601-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/48bc65e66cf8/fbioe-12-1378601-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/e3cbbbf37827/fbioe-12-1378601-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/ee0c91b24ae7/fbioe-12-1378601-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/f718c27bb20d/fbioe-12-1378601-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/372037577d92/fbioe-12-1378601-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0b/11082400/2f4112f0c07d/fbioe-12-1378601-g009.jpg

相似文献

[1]
Synthesis and toxicity assessment of extract-derived gold nanoparticles loaded with doxorubicin in lung cancer cell cultures.

Front Bioeng Biotechnol. 2024-4-26

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Enhanced Stability of Multi-Functionalized Gold Nanoparticles and Potential Anticancer Efficacy on Human Cervical Cancer Cells.

Biomedicines. 2025-7-31

[2]
From Past to Present: Gold Nanoparticles (AuNPs) in Daily LifeSynthesis Mechanisms, Influencing Factors, Characterization, Toxicity, and Emerging Applications in Biomedicine, Nanoelectronics, and Materials Science.

ACS Omega. 2025-7-30

[3]
Biogenically synthesized gold nanocarrier ameliorated antiproliferative and apoptotic efficacy of doxorubicin against lung cancer.

Front Pharmacol. 2024-10-29

本文引用的文献

[1]
Emerging Trends in Zinc Ferrite Nanoparticles for Biomedical and Environmental Applications.

Appl Biochem Biotechnol. 2024-2

[2]
Quantification of Spent Coffee Ground Extracts by Roast and Brew Method, and Their Utility in a Green Synthesis of Gold and Silver Nanoparticles.

Molecules. 2022-8-11

[3]
Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFeO Nanoparticles for Anticancer and Antibacterial Applications.

Nanomaterials (Basel). 2022-7-3

[4]
Synthesis approach-dependent antiviral properties of silver nanoparticles and nanocomposites.

J Nanostructure Chem. 2022

[5]
Delineating the Role of Tailored Gold Nanostructures at the Biointerface.

ACS Appl Bio Mater. 2021-12-20

[6]
Biological Impact of Phenolic Compounds from Coffee on Colorectal Cancer.

Pharmaceuticals (Basel). 2021-8-3

[7]
The 35th Anniversary of the Discovery of EPR Effect: A New Wave of Nanomedicines for Tumor-Targeted Drug Delivery-Personal Remarks and Future Prospects.

J Pers Med. 2021-3-22

[8]
Health Effects of Coffee: Mechanism Unraveled?

Nutrients. 2020-6-20

[9]
Applications and strategies in nanodiagnosis and nanotherapy in lung cancer.

Semin Cancer Biol. 2021-2

[10]
Doxorubicin-carboxymethyl xanthan gum capped gold nanoparticles: Microwave synthesis, characterization, and anti-cancer activity.

Carbohydr Polym. 2019-10-22

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