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多发性硬化症患者多次使用钆布醇后参照脑白质的 T1 加权灰质信号强度改变。

T1-weighted Grey Matter Signal Intensity Alterations After Multiple Administrations of Gadobutrol in Patients with Multiple Sclerosis, Referenced to White Matter.

机构信息

University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Bern, Switzerland.

Institute of Radiology and Neuroradiology, Tiefenau Hospital, Inselgroup, Bern, Switzerland.

出版信息

Sci Rep. 2018 Nov 15;8(1):16844. doi: 10.1038/s41598-018-35186-w.

DOI:10.1038/s41598-018-35186-w
PMID:30442977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6237839/
Abstract

The aim of the study was to investigate the signal-intensity-(SI)-ratio changes in the basal ganglia, the pulvinar thalami (PN), and the dentate nucleus (DN) using frontal white matter (FWM) as reference area, in patients with multiple sclerosis after frequent administrations of gadobutrol. A control group (group I) was compared to three stratified patient groups (group II: mean applications of gadobutrol 3.7; group III: 7.5 applications; group IV: 13.8 applications). SI-ratios of the pallidum, putamen, caudate nucleus, and pulvinar thalami were calculated with: 1. FWM, and 2. PN. DN-to-pons and DN-to-FWM ratios were also calculated. The most significant SI-ratio-changes were found by comparing group I and IV for both reference values. However, by using FWM as reference an SI-ratio increase was observed, while an SI-ratio decrease was seen if referenced to the PN. DN-to-FWM showed an SI-ratio increase, too. The PN revealed a significant SI-ratio increase itself, correlating with the number of gadolinium applications, when referenced to FWM. Therefore, SI-ratio calculations using the thalamus as reference might be flawed. In addition, a minor gadolinium accumulation is possible, if FWM was used as reference area. Further studies are necessary to verify our results.

摘要

本研究旨在探讨多次使用钆布醇后，多发性硬化症患者的基底节区、丘脑底核（PN）和齿状核（DN）的信号强度（SI）比值变化，以额白质（FWM）为参照区。将对照组（I 组）与 3 个分层患者组（II 组：平均使用 3.7 次钆布醇；III 组：7.5 次；IV 组：13.8 次）进行比较。计算了苍白球、壳核、尾状核和丘脑底核的 SI 比值，使用：1. FWM 和 2. PN。还计算了 DN 与脑桥和 DN 与 FWM 的比值。通过比较参考值为 I 组和 IV 组，发现了最显著的 SI 比值变化。然而，当以 FWM 为参照时，观察到 SI 比值增加，而当以 PN 为参照时，观察到 SI 比值减少。DN 与 FWM 的比值也显示 SI 比值增加。当以 FWM 为参照时，PN 自身的 SI 比值也显著增加，与钆的应用次数相关。因此，以丘脑为参照进行 SI 比值计算可能存在缺陷。此外，如果以 FWM 为参照区，可能会出现少量的钆累积。需要进一步的研究来验证我们的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/6237839/8f51f80893bc/41598_2018_35186_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/6237839/d69c7485ec92/41598_2018_35186_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/6237839/37b5075ad811/41598_2018_35186_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/6237839/8f51f80893bc/41598_2018_35186_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/6237839/d69c7485ec92/41598_2018_35186_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/6237839/37b5075ad811/41598_2018_35186_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16eb/6237839/8f51f80893bc/41598_2018_35186_Fig3_HTML.jpg

相似文献

[1]
T1-weighted Grey Matter Signal Intensity Alterations After Multiple Administrations of Gadobutrol in Patients with Multiple Sclerosis, Referenced to White Matter.

Sci Rep. 2018-11-15

[2]
Intraindividual Analysis of Signal Intensity Changes in the Dentate Nucleus After Consecutive Serial Applications of Linear and Macrocyclic Gadolinium-Based Contrast Agents.

Invest Radiol. 2016-11

[3]
Gadolinium Brain Deposition after Macrocyclic Gadolinium Administration: A Pediatric Case-Control Study.

Radiology. 2017-6-21

[4]
Increasing signal intensity within the dentate nucleus and globus pallidus on unenhanced T1W magnetic resonance images in patients with relapsing-remitting multiple sclerosis: correlation with cumulative dose of a macrocyclic gadolinium-based contrast agent, gadobutrol.

Eur Radiol. 2016-3

[5]
Repeated intravenous administration of gadobutrol does not lead to increased signal intensity on unenhanced T1-weighted images-a voxel-based whole brain analysis.

Eur Radiol. 2017-3-13

[6]
Comparison of Unenhanced T1-Weighted Signal Intensities Within the Dentate Nucleus and the Globus Pallidus After Serial Applications of Gadopentetate Dimeglumine Versus Gadobutrol in a Pediatric Population.

Invest Radiol. 2018-2

[7]
Signal Change in the Dentate Nucleus on T1-Weighted MR Images After Multiple Administrations of Gadopentetate Dimeglumine Versus Gadobutrol.

AJR Am J Roentgenol. 2015-12-23

[8]
Weekly enhanced T1-weighted MRI with Gadobutrol injections in MS patients: Is there a signal intensity increase in the dentate nucleus and the globus pallidus?

Eur J Radiol. 2018-6-19

[9]
Effects of serial macrocyclic-based contrast materials gadoterate meglumine and gadobutrol administrations on gadolinium-related dentate nuclei signal increases in unenhanced T1-weighted brain: a retrospective study in 158 multiple sclerosis (MS) patients.

Radiol Med. 2018-2

[10]
High-Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted Images: Evaluation of the Macrocyclic Gadolinium-Based Contrast Agent Gadobutrol.

Invest Radiol. 2015-12

引用本文的文献

[1]
Gadolinium Contrast Agent Deposition in Children.

J Magn Reson Imaging. 2025-1

[2]
Does the proteasome inhibitor bortezomib sensitize to DNA-damaging therapy in gastroenteropancreatic neuroendocrine neoplasms? - A preclinical assessment in vitro and in vivo.

Neoplasia. 2021-1

[3]
Spine MRI in Spontaneous Intracranial Hypotension for CSF Leak Detection: Nonsuperiority of Intrathecal Gadolinium to Heavily T2-Weighted Fat-Saturated Sequences.

AJNR Am J Neuroradiol. 2020-6-18

[4]
Visible T1-hyperintensity of the dentate nucleus after multiple administrations of macrocyclic gadolinium-based contrast agents: yes or no?

Insights Imaging. 2019-9-4

本文引用的文献

[1]
Spatiotemporal Pattern of Gadodiamide-Related T1 Hyperintensity Increase Within the Deep Brain Nuclei.

Invest Radiol. 2018-12

[2]
Multiple Administrations of Gadobutrol in the Pediatric Brain: No Change in T1 Signal at MRI.

Radiology. 2018-6-26

[3]
Dentate Nucleus Signal Intensity Decrease on T1-weighted MR Images after Switching from Gadopentetate Dimeglumine to Gadobutrol.

Radiology. 2018-3-14

[4]
T1 Shortening in the Globus Pallidus after Multiple Administrations of Gadobutrol: Assessment with a Multidynamic Multiecho Sequence.

Radiology. 2017-11-1

[5]
Up to 52 administrations of macrocyclic ionic MR contrast agent are not associated with intracranial gadolinium deposition: Multifactorial analysis in 385 patients.

PLoS One. 2017-8-31

[6]
Brain relaxometry after macrocyclic Gd-based contrast agent.

Clin Neuroradiol. 2017-12

[7]
Comparison of Gadolinium Concentrations within Multiple Rat Organs after Intravenous Administration of Linear versus Macrocyclic Gadolinium Chelates.

Radiology. 2017-6-19

[8]
Histology and Gadolinium Distribution in the Rodent Brain After the Administration of Cumulative High Doses of Linear and Macrocyclic Gadolinium-Based Contrast Agents.

Invest Radiol. 2017-6

[9]
Repeated intravenous administration of gadobutrol does not lead to increased signal intensity on unenhanced T1-weighted images-a voxel-based whole brain analysis.

Eur Radiol. 2017-3-13

[10]
Quantification and Assessment of the Chemical Form of Residual Gadolinium in the Brain After Repeated Administration of Gadolinium-Based Contrast Agents: Comparative Study in Rats.

Invest Radiol. 2017-7

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