Oyemade A, Odelola A
Afr J Med Med Sci. 1985 Mar-Jun;14(1-2):27-30.
The present study attempts to establish a relationship between maternal rubella and congenital deafness in Nigeria. For the purpose of the survey, the immunological status with respect to rubella infection of 179 healthy but deaf school children (study group) and 248 school children with normal hearing (control group) was determined. The serological technique employed was the haemagglutination inhibition (HI) test. The percentage of immunized persons ranged from 48.6 to 74.2% in the study group and 55.3 to 68.3% in the control group. Furthermore, the HI antibody titres for the study group were not significantly different from those of the control group although both groups were found to exhibit low HI antibody titres. The presence of low titres of HI antibodies in both groups and the absence of any significant correlation between the state of hearing and HI antibody levels seem to indicate that intrauterine rubella is not an important cause of congenital deafness in Nigeria.
本研究试图在尼日利亚确立母亲感染风疹与先天性耳聋之间的关系。为了进行此项调查，测定了179名健康但失聪的学童（研究组）和248名听力正常的学童（对照组）的风疹感染免疫状态。所采用的血清学技术是血凝抑制（HI）试验。研究组中免疫者的百分比在48.6%至74.2%之间，对照组在55.3%至68.3%之间。此外，研究组的HI抗体效价与对照组的没有显著差异，尽管两组的HI抗体效价都较低。两组中都存在低滴度的HI抗体，且听力状况与HI抗体水平之间不存在任何显著相关性，这似乎表明在尼日利亚，子宫内风疹并非先天性耳聋的重要病因。
