Gumpel S M, Hayes K, Dudgeon J A
Br Med J. 1971 May 8;2(5757):300-4. doi: 10.1136/bmj.2.5757.300.
Rubella antibody was detected in 85 (61%) of 139 children aged from 6 months to 7 years with congenital perceptive deafness. Of the 112 children who were aged under 4 years 61 (54%) had rubella antibody (seropositive) compared with 7.1% in randomly selected children of the same age. A close correlation was found between the presence of antibody in children with perceptive deafness and (1) a maternal history of rash or contact in early pregnancy, and (2) with the presence of other rubella-type defects. Intrauterine rubella was thought to be the cause of the deafness in 82 (59%) of the 139 children, in 60 of whom deafness was the only rubella defect detected. Thus intrauterine rubella should be considered a likely cause of congenital perceptive deafness in a child under 4 years in whom rubella antibody is present.
在139名6个月至7岁的先天性感音神经性耳聋儿童中，85名（61%）检测到风疹抗体。在112名4岁以下儿童中，61名（54%）有风疹抗体（血清阳性），而在随机选取的同年龄儿童中这一比例为7.1%。在感音神经性耳聋儿童中，抗体的存在与以下两点密切相关：（1）母亲在妊娠早期有皮疹或接触史；（2）存在其他风疹类型的缺陷。139名儿童中，82名（59%）的耳聋被认为是由宫内风疹引起的，其中60名儿童的耳聋是检测到的唯一风疹缺陷。因此，对于4岁以下存在风疹抗体的儿童，宫内风疹应被视为先天性感音神经性耳聋的一个可能病因。
