Centre for Biomimetic Sensor Science, School of Materials Science and Engineering , Nanyang Technological University , 50 Nanyang Drive , 637553 Singapore.
School of Biological Sciences , Nanyang Technological University , 60 Nanyang Drive , 637551 Singapore.
Bioconjug Chem. 2018 Jul 18;29(7):2176-2180. doi: 10.1021/acs.bioconjchem.8b00369. Epub 2018 Jun 26.
A new glucose-responsive insulin delivery system is fabricated using biomimetic peptide coacervates derived from the Humboldt squid (Dosidicus Gigas) beak. Both insulin and glucose oxidase are coencapsulated within coacervate microdroplets. The glucose oxidase quickly responds to increasing glucose levels to generate a local acidic environment, thereby rapidly triggering the dissociation of pH-sensitive coacervates to release the insulin cargo. The rate of insulin release is dependent on the glucose level, increases under hyperglycemic conditions, and decreases under normoglycemic conditions. This glucose responsiveness mimics pancreatic β-cell function by releasing insulin according to glucose levels.
一种使用源自洪堡鱿鱼（Dosidicus Gigas）喙的仿生肽凝聚物制备的新型葡萄糖响应型胰岛素递药系统。胰岛素和葡萄糖氧化酶都被共包封在凝聚物微滴内。葡萄糖氧化酶迅速响应升高的葡萄糖水平以产生局部酸性环境，从而快速触发 pH 敏感凝聚物的解离以释放胰岛素货物。胰岛素的释放速率取决于葡萄糖水平，在高血糖条件下增加，在正常血糖条件下降低。这种葡萄糖响应性通过根据葡萄糖水平释放胰岛素来模拟胰腺β细胞的功能。
