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人白蛋白片段纳米颗粒作为紫杉醇载体以提高抗癌疗效

Human Albumin Fragments Nanoparticles as PTX Carrier for Improved Anti-cancer Efficacy.

作者信息

Ge Liang, You Xinru, Huang Jun, Chen Yuejian, Chen Li, Zhu Ying, Zhang Yuan, Liu Xiqiang, Wu Jun, Hai Qian

机构信息

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.

School of Pharmacy, Xinjiang Medical University, Ürümqi, China.

出版信息

Front Pharmacol. 2018 Jun 12;9:582. doi: 10.3389/fphar.2018.00582. eCollection 2018.

DOI:10.3389/fphar.2018.00582
PMID:29946256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6005878/
Abstract

For enhanced anti-cancer performance, human serum albumin fragments (HSAFs) nanoparticles (NPs) were developed as paclitaxel (PTX) carrier in this paper. Human albumins were broken into fragments via degradation and crosslinked by genipin to form HSAF NPs for better biocompatibility, improved PTX drug loading and sustained drug release. Compared with crosslinked human serum albumin NPs, the HSAF-NPs showed relative smaller particle size, higher drug loading, and improved sustained release. Cellular and animal results both indicated that the PTX encapsulated HSAF-NPs have shown good anti-cancer performance. And the anticancer results confirmed that NPs with fast cellular internalization showed better tumor inhibition. These findings will not only provide a safe and robust drug delivery NP platform for cancer therapy, but also offer fundamental information for the optimal design of albumin based NPs.

摘要

为了增强抗癌性能，本文开发了人血清白蛋白片段（HSAFs）纳米颗粒（NPs）作为紫杉醇（PTX）载体。人白蛋白通过降解被分解成片段，并通过京尼平交联形成HSAF NPs，以实现更好的生物相容性、提高PTX药物负载量和持续药物释放。与交联人血清白蛋白NPs相比，HSAF-NPs粒径相对更小、药物负载量更高且缓释性能得到改善。细胞和动物实验结果均表明，包裹PTX的HSAF-NPs具有良好的抗癌性能。抗癌结果证实，细胞内化迅速的NPs表现出更好的肿瘤抑制作用。这些发现不仅将为癌症治疗提供一个安全且强大的药物递送NP平台，还将为基于白蛋白的NPs的优化设计提供基础信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60d/6005878/1a01eb5d8b15/fphar-09-00582-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60d/6005878/7d01dd7d4cf1/fphar-09-00582-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60d/6005878/2952e2a87e19/fphar-09-00582-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60d/6005878/7fd93cea2310/fphar-09-00582-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60d/6005878/1112e1935912/fphar-09-00582-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60d/6005878/e57b005787db/fphar-09-00582-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60d/6005878/1a01eb5d8b15/fphar-09-00582-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60d/6005878/7d01dd7d4cf1/fphar-09-00582-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60d/6005878/2952e2a87e19/fphar-09-00582-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60d/6005878/7fd93cea2310/fphar-09-00582-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60d/6005878/1112e1935912/fphar-09-00582-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60d/6005878/e57b005787db/fphar-09-00582-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a60d/6005878/1a01eb5d8b15/fphar-09-00582-g006.jpg

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