Qu Ying, Chu BingYang, Shi Kun, Peng JinRong, Qian ZhiYong
J Biomed Nanotechnol. 2017 Dec 1;13(12):1598-1618. doi: 10.1166/jbn.2017.2475.
Polymeric micelles have presented superior delivery properties for poorly water-soluble chemotherapeutic agents. However, it remains discouraging that there may be some additional short or long-term toxicities caused by the metabolites of high quantities of carriers. If carriers had simultaneous therapeutic effects with the drug, these issues would not be a concern. For this, carriers not only simply act as drug carriers, but also exert an intrinsic therapeutic effect as a therapeutic agent. The functional micellar carriers would be beneficial to maximize the anticancer effect, overcome the drug resistance and reduce the systemic toxicity. In this review, we aim to summarize the recent progress on the development of functional micellar carriers with intrinsic anticancer activities for the delivery of anticancer drugs. This review focuses on the design strategies, properties of carriers and the drug loading behavior. In addition, the combinational therapeutic effects between carriers and chemotherapeutic agents are also discussed.
聚合物胶束对水溶性差的化疗药物具有优异的递送性能。然而，大量载体的代谢产物可能会引起一些额外的短期或长期毒性，这仍然令人沮丧。如果载体能与药物同时发挥治疗作用，这些问题就不会成为关注点。为此，载体不仅简单地充当药物载体，还作为治疗剂发挥内在治疗作用。功能性胶束载体将有利于最大化抗癌效果、克服耐药性并降低全身毒性。在本综述中，我们旨在总结用于递送抗癌药物的具有内在抗癌活性的功能性胶束载体开发的最新进展。本综述重点关注设计策略、载体性质和药物负载行为。此外，还讨论了载体与化疗药物之间的联合治疗效果。
