CAS Center for Excellence in Nanoscience, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083, P. R. China.
School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Adv Mater. 2018 Aug;30(32):e1801895. doi: 10.1002/adma.201801895. Epub 2018 Jun 26.
Implantable medical devices provide an effective therapeutic approach for neurological and cardiovascular diseases. With the development of transient electronics, a new power source with biocompatibility, controllability, and bioabsorbability becomes an urgent demand for medical sciences. Here, various fully bioabsorbable natural-materials-based triboelectric nanogenerators (BN-TENGs), in vivo, are developed. The "triboelectric series" of five natural materials is first ranked, it provides a basic knowledge for materials selection and device design of the TENGs and other energy harvesters. Various triboelectric outputs of these natural materials are achieved by a single material and their pairwise combinations. The maximum voltage, current, and power density reach up to 55 V, 0.6 µA, and 21.6 mW m , respectively. The modification of silk fibroin encapsulation film makes the operation time of the BN-TENG tunable from days to weeks. After completing its function, the BN-TENG can be fully degraded and resorbed in Sprague-Dawley rats, which avoids a second operation and other side effects. Using the proposed BN-TENG as a voltage source, the beating rates of dysfunctional cardiomyocyte clusters are accelerated and the consistency of cell contraction is improved. This provides a new and valid solution to treat some heart diseases such as bradycardia and arrhythmia.
植入式医疗器械为神经和心血管疾病提供了一种有效的治疗方法。随着瞬态电子学的发展，一种具有生物相容性、可控性和可生物吸收性的新型电源成为医学科学的迫切需求。在这里，各种完全可生物吸收的基于天然材料的摩擦纳米发电机（BN-TENG）在体内得到了发展。首先对五种天然材料的“摩擦电序列”进行了排序，为 TENG 和其他能量收集器的材料选择和器件设计提供了基础知识。通过单一材料及其组合对这些天然材料的各种摩擦电输出进行了实现。最大电压、电流和功率密度分别达到 55 V、0.6 µA 和 21.6 mW m-2。丝素蛋白封装膜的修饰使 BN-TENG 的工作时间可从几天调整到几周。完成其功能后，BN-TENG 可在 Sprague-Dawley 大鼠中完全降解和再吸收，避免了二次手术和其他副作用。使用所提出的 BN-TENG 作为电压源，可以加速功能失调的心肌细胞簇的跳动速度，并提高细胞收缩的一致性。这为治疗心动过缓和心律失常等一些心脏病提供了一种新的有效解决方案。
