Organic Chemistry Division, CSIR-National Chemical Laboratory, Pune-411008, India.
Org Biomol Chem. 2018 Jul 18;16(28):5081-5085. doi: 10.1039/c8ob01032c.
A catalyst bound α-aminoalkyl radical intermediate from iminium is developed to control its formation and reactivity with aerobic oxygen. The influence of the catalyst was demonstrated via the ease of radical intermediate formation and its subsequent reactivity, including the first catalyst-controlled enantioselective aerobic oxidation with a chiral phosphite catalyst.
开发了一种与亚胺结合的α-氨基烷基自由基中间体的催化剂，以控制其形成和与需氧氧的反应性。通过自由基中间体形成的容易程度及其随后的反应性，包括使用手性亚磷酸酯催化剂的首次催化剂控制的对映选择性需氧氧化，证明了催化剂的影响。
