LaeB 的缺失导致在构巢曲霉中发现了新型的聚酮化合物。
Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans.
机构信息
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
出版信息
Org Biomol Chem. 2018 Jul 11;16(27):4973-4976. doi: 10.1039/c8ob01326h.
By disruption of LaeB, a global regulator recently characterized in Aspergillus nidulans, eight cryptic compounds in the mutant were identified, including seven polyketides and one NRPS-like product. Among the isolates, two phthalides and two dibenzo[1,4]dioxins are new compounds, revealing that the genetic manipulation of the global regulator represents a promising approach for the discovery of novel natural products in fungi.
通过破坏 Aspergillus nidulans 中最近被表征的全局调控因子 LaeB，在突变体中鉴定出了八种隐色化合物，包括七种聚酮化合物和一种 NRPS 样产物。在这些分离物中，两种邻苯二甲酸酐和两种二苯并[1,4]二恶英是新化合物，这表明对全局调控因子的遗传操作代表了在真菌中发现新型天然产物的一种很有前途的方法。
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