Verdonck L F, van Heugten H, de Gast G C
Blood. 1985 Oct;66(4):921-5.
The effect of cytomegalovirus (CMV) infection on hematopoietic recovery after marrow-ablative chemoradiotherapy followed by autologous bone marrow transplantation (BMT) was studied in patients with non-Hodgkin's lymphoma of high-grade malignancy and in patients with acute leukemia. The recovery of platelets after autologous BMT occurred significantly quicker in CMV-negative patients than in CMV-positive patients (platelets greater than 50,000 per cubic millimeter after 21 1/2 v 40 days, respectively). No differences in the recovery of neutrophils were found between those with or without CMV infection. CMV-positive patients required significantly more transfusion support with thrombocyte concentrates than CMV-negative patients (three v six thrombocyte concentrates). In conclusion, CMV infections do not influence neutrophil recovery but do delay platelet recovery. As a consequence, patients with a CMV infection, whether primary, reactivated, or latent, require more thrombocyte concentrates, which increases the risk of transfusion-related infections.
在高度恶性非霍奇金淋巴瘤患者和急性白血病患者中，研究了巨细胞病毒（CMV）感染对骨髓清除性放化疗后行自体骨髓移植（BMT）的造血恢复的影响。自体BMT后，CMV阴性患者血小板的恢复明显快于CMV阳性患者（分别在21.5天和40天后血小板计数大于每立方毫米50,000，而CMV阳性患者为40天）。在有无CMV感染的患者中，中性粒细胞恢复情况未发现差异。CMV阳性患者比CMV阴性患者需要显著更多的血小板浓缩物输血支持（分别为3次和6次血小板浓缩物）。总之，CMV感染不影响中性粒细胞的恢复，但会延迟血小板的恢复。因此，CMV感染患者，无论原发性、再激活或潜伏性感染，都需要更多的血小板浓缩物，这增加了输血相关感染的风险。
