缺氧对牛阴茎退缩肌和大鼠肛尾肌神经效应器传递的影响。
The effect of hypoxia on neuroeffector transmission in the bovine retractor penis and rat anococcygeus muscles.
作者信息
Bowman A, McGrath J C
出版信息
Br J Pharmacol. 1985 Aug;85(4):869-75. doi: 10.1111/j.1476-5381.1985.tb11086.x.
Abstract
The effects of reducing the PO2 of the bathing fluid were studied on non-adrenergic non-cholinergic (NANC) transmission in isolated preparations of the bovine retractor penis muscle, the rat anococcygeus muscle, the guinea-pig taenia caeci and the guinea-pig urinary bladder. Hypoxia rapidly and reversibly impaired NANC transmission in the bovine retractor penis and rat anococcygeus muscles but did not affect transmission in the guinea-pig taenia caeci or bladder, suggesting that different NANC mechanisms are involved. Although neurally-evoked relaxation of the bovine retractor penis was impaired by hypoxia, relaxations produced by vasoactive intestinal peptide, prostaglandin E1, sodium nitroprusside or an inhibitory factor isolated from the bovine retractor penis were unaffected. Since the inhibitory factor is similar to, and may actually be the NANC transmitter, the results suggest that the site of action of hypoxia in impairing transmission is prejunctional at the inhibitory nerve endings.
摘要
在牛阴茎退缩肌、大鼠肛尾肌、豚鼠盲肠带和豚鼠膀胱的离体标本中，研究了降低灌流液中氧分压（PO2）对非肾上腺素能非胆碱能（NANC）传递的影响。低氧迅速且可逆地损害了牛阴茎退缩肌和大鼠肛尾肌中的NANC传递，但不影响豚鼠盲肠带或膀胱中的传递，这表明涉及不同的NANC机制。尽管低氧损害了牛阴茎退缩肌由神经诱发的舒张，但血管活性肠肽、前列腺素E1、硝普钠或从牛阴茎退缩肌中分离出的一种抑制因子所产生的舒张不受影响。由于该抑制因子与NANC递质相似，实际上可能就是NANC递质，结果表明低氧损害传递的作用位点是在抑制性神经末梢的节前部位。
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