来自牛阴茎退缩肌的一种抑制因子对豚鼠胃肠道和胆囊的作用。
The effect of an inhibitory factor from the bovine retractor penis on the gastro-intestinal tract and gall bladder of the guinea-pig.
作者信息
Crossley A W, Gillespie J S
出版信息
Br J Pharmacol. 1983 Jan;78(1):213-20. doi: 10.1111/j.1476-5381.1983.tb09382.x.
1 The effect of a smooth muscle inhibitory factor extracted from the bovine retractor penis has been examined on a variety of in vitro smooth muscle preparations from the guinea-pig alimentary canal and on the guinea-pig gall bladder. 2 The inhibitory factor caused relaxation of spontaneous and carbachol-induced tone in the taenia coli, the stomach fundal strip and the duodenum and colon. There was little effect on the ileum. Sensitivity was highest in the taenia coli where the response to the inhibitory factor mimicked the response to stimulation of the non-adrenergic, non-cholinergic (NANC) inhibitory nerves. 3 In the taenia coli the inhibitory response to stimulation of the NANC nerves and to ATP was abolished by apamin 5 x 10(-8) M, whereas this or higher concentrations had no effect on the response to the inhibitory factor. This makes it unlikely that the latter is the neurotransmitter in these NANC nerves. 4 The inhibitory factor had no effect on the gall bladder. Inhibitory responses to field stimulation were obtained in this tissue but these were insensitive to tetrodotoxin in concentrations greater than those needed to block the motor cholinergic nerves.
- 已对从牛阴茎退缩肌中提取的一种平滑肌抑制因子，在豚鼠消化道的多种体外平滑肌制剂以及豚鼠胆囊上进行了研究。2. 该抑制因子可使结肠带、胃底条带、十二指肠和结肠的自发性张力以及卡巴胆碱诱导的张力松弛。对回肠几乎没有影响。在结肠带中敏感性最高，对抑制因子的反应类似于对非肾上腺素能、非胆碱能（NANC）抑制神经刺激的反应。3. 在结肠带中，5×10⁻⁸ M的蜂毒明肽可消除对NANC神经刺激和ATP的抑制反应，而该浓度或更高浓度对抑制因子的反应无影响。这使得后者不太可能是这些NANC神经中的神经递质。4. 该抑制因子对胆囊没有影响。在此组织中对场刺激获得了抑制反应，但这些反应对浓度高于阻断运动胆碱能神经所需浓度的河豚毒素不敏感。
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