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Do trials that report a neutral or negative treatment effect improve the care of critically ill patients? No.

作者信息

Vincent Jean-Louis, Marini John J, Pesenti Antonio

机构信息

Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.

Regions Hospital, University of Minnesota, Minneapolis/St. Paul, MN, USA.

出版信息

Intensive Care Med. 2018 Nov;44(11):1989-1991. doi: 10.1007/s00134-018-5220-y. Epub 2018 Jun 11.

DOI:10.1007/s00134-018-5220-y
PMID:29947879
Abstract
摘要

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N Engl J Med. 2018 Mar 1;378(9):809-818. doi: 10.1056/NEJMoa1705716.
2
Time to Rethink the Approach to Treating Acute Respiratory Distress Syndrome.是时候重新思考治疗急性呼吸窘迫综合征的方法了。
JAMA. 2018 Feb 20;319(7):664-666. doi: 10.1001/jama.2017.21900.
3
Adjunctive Glucocorticoid Therapy in Patients with Septic Shock.辅助糖皮质激素治疗脓毒性休克患者。
重症监护中的人血白蛋白溶液:综述
J Intensive Care Soc. 2021 Aug;22(3):248-254. doi: 10.1177/1751143720961245. Epub 2020 Sep 30.
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Precision medicine for COVID-19: a call for better clinical trials.针对2019冠状病毒病的精准医学:呼吁开展更好的临床试验。
Crit Care. 2020 Jun 2;24(1):282. doi: 10.1186/s13054-020-03002-5.
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Who may benefit most from future vitamin D intervention trials: do not forget patients on continuous renal replacement therapy.谁可能从未来的维生素D干预试验中获益最多:不要忘记接受持续肾脏替代治疗的患者。
Crit Care. 2020 Apr 28;24(1):180. doi: 10.1186/s13054-020-02910-w.
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The premature closure of ROMPA clinical trial: mortality reduction in septic shock by plasma adsorption.ROMPA 临床试验提前关闭:血浆吸附降低脓毒性休克患者死亡率。
BMJ Open. 2019 Dec 3;9(12):e030139. doi: 10.1136/bmjopen-2019-030139.
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