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Do trials that report a neutral or negative treatment effect improve the care of critically ill patients? Yes.

作者信息

Perner Anders, Finfer Simon

机构信息

Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, The George Institute of Global Health, University of New South Wales, Sydney, NSW, Australia.

出版信息

Intensive Care Med. 2018 Nov;44(11):1985-1988. doi: 10.1007/s00134-018-5129-5. Epub 2018 Jun 11.

DOI:10.1007/s00134-018-5129-5
PMID:29947880
Abstract
摘要

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本文引用的文献

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Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults.红细胞输注年龄与危重症成年患者结局的关系。
N Engl J Med. 2017 Nov 9;377(19):1858-1867. doi: 10.1056/NEJMoa1707572. Epub 2017 Sep 27.
2
Interventions affecting mortality in critically ill and perioperative patients: A systematic review of contemporary trials.影响危重症及围手术期患者死亡率的干预措施：当代试验的系统评价
J Crit Care. 2017 Oct;41:107-111. doi: 10.1016/j.jcrc.2017.05.005. Epub 2017 May 4.
3
A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators.
一项针对感染性休克早期目标导向治疗的系统评价和荟萃分析：ARISE、ProCESS 和 ProMISe 研究人员。
Intensive Care Med. 2015 Sep;41(9):1549-60. doi: 10.1007/s00134-015-3822-1. Epub 2015 May 8.
4
Age of transfused blood in critically ill adults.危重症成人输注血液的年龄。
N Engl J Med. 2015 Apr 9;372(15):1410-8. doi: 10.1056/NEJMoa1500704. Epub 2015 Mar 17.
5
Mortality in Multicenter Critical Care Trials: An Analysis of Interventions With a Significant Effect.多中心重症监护试验中的死亡率：具有显著效果的干预措施分析。
Crit Care Med. 2015 Aug;43(8):1559-68. doi: 10.1097/CCM.0000000000000974.
6
The platform trial: an efficient strategy for evaluating multiple treatments.平台试验：一种评估多种治疗方法的有效策略。
JAMA. 2015 Apr 28;313(16):1619-20. doi: 10.1001/jama.2015.2316.
7
Lower versus higher hemoglobin threshold for transfusion in septic shock.较低与较高血红蛋白阈值用于感染性休克患者输血。
N Engl J Med. 2014 Oct 9;371(15):1381-91. doi: 10.1056/NEJMoa1406617. Epub 2014 Oct 1.
8
Targeted temperature management at 33°C versus 36°C after cardiac arrest.心脏骤停后 33°C 与 36°C 的目标温度管理。
N Engl J Med. 2013 Dec 5;369(23):2197-206. doi: 10.1056/NEJMoa1310519. Epub 2013 Nov 17.
9
Critical care--an all-encompassing specialty.重症监护——一个涵盖面极广的专业领域。
N Engl J Med. 2013 Aug 15;369(7):669-70. doi: 10.1056/NEJMe1304035.
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High-frequency oscillation in early acute respiratory distress syndrome.早期急性呼吸窘迫综合征中的高频振荡。
N Engl J Med. 2013 Feb 28;368(9):795-805. doi: 10.1056/NEJMoa1215554. Epub 2013 Jan 22.