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先天淋巴细胞在人类免疫系统中的作用。

The roles for innate lymphoid cells in the human immune system.

机构信息

Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

出版信息

Semin Immunopathol. 2018 Jul;40(4):407-419. doi: 10.1007/s00281-018-0688-7. Epub 2018 Jun 12.

DOI:10.1007/s00281-018-0688-7
PMID:29948108
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6060849/
Abstract

From constituting a novel and obscure cell population, innate lymphoid cells (ILCs) are now accepted as a self-evident part of the immune system, contributing with unique and complementary functions to immunity by production of effector cytokines and interaction with other cell types. In this review, we discuss the redundant and complementary roles of the highly plastic human ILCs and their interaction with other immune cells with the ultimate aim of placing ILCs in a wider context within the human immune system.

摘要

从构成一个新颖而模糊的细胞群体开始，先天淋巴细胞 (ILC) 现在被认为是免疫系统的一个不言而喻的组成部分，通过产生效应细胞因子和与其他细胞类型相互作用，发挥独特而互补的免疫功能。在这篇综述中，我们讨论了高度可塑性的人类 ILC 的冗余和互补作用及其与其他免疫细胞的相互作用，最终目的是将 ILC 置于人类免疫系统的更广泛背景中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9691/6060849/35bc687aec7d/281_2018_688_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9691/6060849/35bc687aec7d/281_2018_688_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9691/6060849/35bc687aec7d/281_2018_688_Fig1_HTML.jpg

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Divergent Roles of Interferon-γ and Innate Lymphoid Cells in Innate and Adaptive Immune Cell-Mediated Intestinal Inflammation.
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