Post-Coma Unit, IRCCS Santa Lucia Foundation, Rome, Italy.
Clinical Laboratory of Experimental Neurorehabilitation, IRCCS Santa Lucia Foundation, Rome, Italy.
Neurol Sci. 2018 Sep;39(9):1651-1656. doi: 10.1007/s10072-018-3466-3. Epub 2018 Jun 15.
The Brief Post-Coma Scale (BPCS) is an easy diagnostic tool for individuals with disorders of consciousness (DoC), in a reduced version from a previously Post-Coma Scale, that could distinguish patients in the minimally conscious state (MCS) from those in unresponsive wakefulness syndrome (UWS), formerly defined as vegetative state (VS).
Aim of the study was to assess the diagnostic validity of the BPCS in comparison with the Coma Recovery Scale-Revised (CRS-R), in its Italian validated version, the Disability Rating Scale (DRS), the Level of Cognitive Functioning (LCF), and the Glasgow Outcome Scale (GOS).
In an Italian multicenter study on 545 patients with DoC, 36 post-acute rehabilitation wards, 32 long-term care centers, and 2 family associations participated to data collection.
Statistically significant correlations were found between the BPCS and the other clinical scales: R = 0.586 (p < 0.001) with LCF, R = - 0.566 (p < 0.001) with DRS, R = 0.622 (p < 0.001) with CRS-R. The BPCS scores resulted significantly correlated with the time from acute event (R = 0.117, p = 0.006). Patients with GOS score 2 had mean BPCS of 1.84 ± 1.19, whereas those with GOS 3 had significantly higher scores 3.88 ± 1.71 (p < 0.001). Similarly, in patients with vegetative state/UWS (VS/UWS), the mean BPSC score was 1.71 ± 1.09, significantly lower (p < 0.001) than that of patients with minimally conscious state (BPCS = 3.83 ± 1.29). Finally, the agreement of the BPCS and clinical diagnosis was of 84.4%, with an odds ratio OR = 3.781 (95% CI = 3.026-4.725, p < 0.001).
The BPCS has demonstrated statistically significant correlations with the most commonly used scales in persons with DoC.
简要昏迷后量表（BPCS）是一种用于诊断意识障碍（DoC）患者的简便工具，其为先前昏迷后量表的简化版本，可将最小意识状态（MCS）患者与无反应性觉醒综合征（UWS）患者（以前定义为植物状态（VS））区分开来。
本研究旨在评估 BPCS 在意大利经过验证的版本即残疾评定量表（DRS）、认知功能水平量表（LCF）和格拉斯哥结局量表（GOS）与 coma recovery scale-revised（CRS-R）的诊断有效性比较。
在一项针对 545 名意识障碍患者的意大利多中心研究中，36 个急性康复病房、32 个长期护理中心和 2 个家庭协会参与了数据收集。
BPCS 与其他临床量表之间存在显著的相关性：与 LCF 相关，R=0.586（p<0.001），与 DRS 相关，R=-0.566（p<0.001），与 CRS-R 相关，R=0.622（p<0.001）。BPCS 评分与急性事件后的时间呈显著相关（R=0.117，p=0.006）。GOS 评分 2 的患者 BPCS 平均得分为 1.84±1.19，而 GOS 评分 3 的患者 BPCS 得分显著更高，为 3.88±1.71（p<0.001）。同样，在植物状态/无反应性觉醒综合征（VS/UWS）患者中，BPCS 的平均得分是 1.71±1.09，显著低于（p<0.001）最小意识状态患者的得分（BPCS=3.83±1.29）。最后，BPCS 与临床诊断的一致性为 84.4%，优势比 OR=3.781（95%CI=3.026-4.725，p<0.001）。
BPCS 与意识障碍患者最常用的量表之间存在统计学显著的相关性。
