Cesur Sevim, Çardaközü Tülay, Kuş Alparslan, Türkyılmaz Neşe, Yavuz Ömer
Department of Anesthesiology and Reanimation, Kocaeli University of Medical Faculty, Izmit, Kocaeli, Turkey.
Department of General Surgery, Kocaeli University of Medical Faculty, Izmit, Kocaeli, Turkey.
J Clin Monit Comput. 2019 Apr;33(2):249-257. doi: 10.1007/s10877-018-0163-y. Epub 2018 Jun 14.
Intraoperative fluid management is quite important in terms of postoperative organ perfusion and complications. Different fluid management protocols are in use for this purpose. Our primary goal was to compare the effects of conventional fluid management (CFM) with the Pleth Variability Index (PVI) guided goal-directed fluid management (GDFM) protocols on the amount of crystalloids administered, blood lactate, and serum creatinine levels during the intraoperative period. The length of hospital stay was our secondary goal. Seventy ASA I-II elective colorectal surgery patients were randomly assigned to CFM or GDFM for fluid management. The hemodynamic data and the data obtained from ABG were recorded at the end of induction and during the follow-up period at 1 h intervals. In the preoperative period and at 24 h postoperatively, blood samples were taken for the measurement of hemoglobin, Na, K, Cl, serum creatinine, albumin and blood lactate. In the first 24 h after surgery, oliguria and the time of first bowel movement were recorded. Length of hospital stay was also recorded. Intraoperative crystalloid administration and urine output were statistically significantly higher in CFM group (p < 0.001, p: 0.018). The end-surgery fluid balance was significantly lower in Group GDFM. Preoperative and postoperative Na, K, Cl, serum albumin, serum creatinine, lactate and hemoglobin values were similar between the groups. The time to passage of stool was significantly short in Group-GDFM compared to Group-CFM (p = 0.016). The length of hospital stay was found to be similar in both group. PVI-guided GDFM might be an alternative to CFM in ASA I-II patients undergoing elective colorectal surgery. However, further studies need to be carried out to search the efficiency and safety of PVI.
术中液体管理对于术后器官灌注和并发症而言相当重要。为此采用了不同的液体管理方案。我们的主要目标是比较传统液体管理(CFM)与脉搏变异指数(PVI)引导的目标导向液体管理(GDFM)方案在术中晶体液输注量、血乳酸和血清肌酐水平方面的效果。住院时间是我们的次要目标。70例美国麻醉医师协会(ASA)分级为I-II级的择期结直肠手术患者被随机分配至CFM组或GDFM组进行液体管理。诱导结束时以及随访期间每隔1小时记录血流动力学数据和动脉血气(ABG)数据。在术前和术后24小时,采集血样以测定血红蛋白、钠、钾、氯、血清肌酐、白蛋白和血乳酸。记录术后头24小时的少尿情况和首次排便时间。同时记录住院时间。CFM组术中晶体液输注量和尿量在统计学上显著更高(p < 0.001,p: 0.018)。GDFM组手术结束时的液体平衡显著更低。两组之间术前和术后的钠、钾、氯、血清白蛋白、血清肌酐、乳酸和血红蛋白值相似。与CFM组相比,GDFM组的排便时间显著更短(p = 0.016)。发现两组的住院时间相似。对于接受择期结直肠手术的ASA I-II级患者,PVI引导的GDFM可能是CFM的一种替代方案。然而,需要开展进一步研究以探寻PVI的有效性和安全性。