Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 23 Gh. Marinescu street, 400337, Cluj-Napoca, Romania.
Stem Cell Rev Rep. 2018 Oct;14(5):632-641. doi: 10.1007/s12015-018-9834-9.
Chimerism occurs naturaly throughout gestation and can also occur as a consequence of transfusion and transplantation therapy. It consists of the acquisition and long-term persistence of a genetically distinct population of allogenic cells inside another organism. Previous reports have suggested that feto-maternal microchimerism could exert a beneficial effect on the treatment of hematological and solid tumors in patients treated by PBSCT. In this review we report the mechanism of transplacental fetal stem cell trafficking during pregnancy and the effect of their long-term persistence on autoimmunity, GVHD, PBSCT, cancer and stem cell treatment.
嵌合体在妊娠过程中自然发生，也可因输血和移植治疗而产生。它由另一个生物体中获得并长期存在的遗传上不同的同种异体细胞群组成。先前的报告表明，胎儿-母体微嵌合体可能对接受 PBSCT 治疗的血液系统和实体肿瘤患者的治疗产生有益影响。在这篇综述中，我们报告了妊娠期间胎盘胎儿干细胞迁移的机制，以及它们的长期存在对自身免疫、GVHD、PBSCT、癌症和干细胞治疗的影响。
