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2
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Fetal microchimerism and cancer.胎儿微嵌合体与癌症
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引用本文的文献

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Microchimerism: A new concept.微嵌合体：一个新概念。
J Oral Maxillofac Pathol. 2019 May-Aug;23(2):311. doi: 10.4103/jomfp.JOMFP_85_17.
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Can chimerism explain breast/ovarian cancers in BRCA non-carriers from BRCA-positive families?嵌合体能否解释 BRCA 阳性家族中 BRCA 阴性的乳腺癌/卵巢癌？
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3
Novel insights into the link between fetal cell microchimerism and maternal cancers.关于胎儿细胞微嵌合体与母体癌症之间联系的新见解。
J Cancer Res Clin Oncol. 2016 Aug;142(8):1697-704. doi: 10.1007/s00432-015-2110-3. Epub 2016 Jan 8.
4
Microchimeric Cells, Sex Chromosome Aneuploidies and Cancer.微嵌合细胞、性染色体非整倍性与癌症。
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Fetal cells in the murine maternal lung have well-defined characteristics and are preferentially located in alveolar septum.胎鼠肺内的母体来源细胞具有明确的特征，并且优先定位于肺泡隔。
Stem Cells Dev. 2012 Jan;21(1):158-65. doi: 10.1089/scd.2010.0518. Epub 2011 Oct 14.
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Fetal cell microchimerism and cancer: a nexus of reproduction, immunology, and tumor biology.胎儿细胞微嵌合体与癌症：生殖、免疫与肿瘤生物学的关联。
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本文引用的文献

1
Beneficial effects of fetal-maternal microchimerism on the activated haplo-identical peripheral blood stem cell treatment for cancer.胎儿-母体微嵌合体对单倍体相合外周血干细胞治疗癌症的有益作用。
Cytotherapy. 2008;10(4):331-9. doi: 10.1080/14653240802061146.
2
Decreased bladder cancer growth in parous mice.经产小鼠膀胱肿瘤生长减缓。
Urology. 2008 Sep;72(3):470-3. doi: 10.1016/j.urology.2008.04.028. Epub 2008 Jun 4.
3
Fetal-maternal microchimerism in normal parous females and parous female cancer patients.正常经产女性和经产女性癌症患者中的胎儿-母体微嵌合体。
Exp Hematol. 2008 Sep;36(9):1073-7. doi: 10.1016/j.exphem.2008.03.020. Epub 2008 May 27.
4
Microchimeric fetal cells cluster at sites of tissue injury in lung decades after pregnancy.怀孕数十年后，微嵌合胎儿细胞聚集在肺部组织损伤部位。
Reprod Biomed Online. 2008 Mar;16(3):382-90. doi: 10.1016/s1472-6483(10)60600-1.
5
Case-control study of fetal microchimerism and breast cancer.胎儿微嵌合体与乳腺癌的病例对照研究
PLoS One. 2008 Mar 5;3(3):e1706. doi: 10.1371/journal.pone.0001706.
6
Fetal microchimerism in women with breast cancer.乳腺癌女性中的胎儿微嵌合体。
Cancer Res. 2007 Oct 1;67(19):9035-8. doi: 10.1158/0008-5472.CAN-06-4209.
7
Normal stem cells and cancer stem cells: the niche matters.正常干细胞与癌症干细胞：生态位至关重要。
Cancer Res. 2006 May 1;66(9):4553-7. doi: 10.1158/0008-5472.CAN-05-3986.
8
Microchimerism in female bone marrow and bone decades after fetal mesenchymal stem-cell trafficking in pregnancy.孕期胎儿间充质干细胞迁移数十年后女性骨髓和骨骼中的微嵌合体现象。
Lancet. 2004;364(9429):179-82. doi: 10.1016/S0140-6736(04)16631-2.
9
Transfer of fetal cells with multilineage potential to maternal tissue.具有多向分化潜能的胎儿细胞向母体组织的转移。
JAMA. 2004 Jul 7;292(1):75-80. doi: 10.1001/jama.292.1.75.
10
Microchimerism: an investigative frontier in autoimmunity and transplantation.微嵌合体：自身免疫和移植领域的前沿研究方向。
JAMA. 2004 Mar 3;291(9):1127-31. doi: 10.1001/jama.291.9.1127.

胎儿微嵌合体与癌症

Fetal microchimerism and cancer.

作者信息

Sawicki Janet A

机构信息

Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, USA.

出版信息

Cancer Res. 2008 Dec 1;68(23):9567-9. doi: 10.1158/0008-5472.CAN-08-3008.

DOI:10.1158/0008-5472.CAN-08-3008
PMID:19047129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2638004/
Abstract

The persistence of fetal stem cells with multilineage potential in women who have been pregnant, a phenomenon known as fetal microchimerism, is emerging as a potential contributing factor in certain diseases, including cancer. For example, fetal microchimerism has been implicated in autoimmune disease, wound healing, and cancer. Studies of this phenomenon may provide a novel perspective on cancer in women, including in breast, ovarian, and lung cancers.

摘要

怀孕女性体内具有多向分化潜能的胎儿干细胞的持续存在，即所谓的胎儿微嵌合体现象，正逐渐成为包括癌症在内的某些疾病的一个潜在促成因素。例如，胎儿微嵌合体与自身免疫性疾病、伤口愈合及癌症有关。对这一现象的研究可能为女性癌症，包括乳腺癌、卵巢癌和肺癌，提供新的视角。