miR-765 的上调预示着食管鳞癌患者预后不良。

Up-regulation of miR-765 predicts a poor prognosis in patients with esophageal squamous cell carcinoma.

机构信息

Department of Thoracic Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.

出版信息

Eur Rev Med Pharmacol Sci. 2018 Jun;22(12):3789-3794. doi: 10.26355/eurrev_201806_15261.

DOI:10.26355/eurrev_201806_15261

PMID:29949154

Abstract

OBJECTIVE

Up-regulation of miR-765 in esophageal squamous cell carcinoma (ESCC) has been reported in the previous study. The aim of the present study was to measure the levels of miR-765 expression in ESCC and evaluate its clinical significance in ESCC patients.

PATIENTS AND METHODS

Quantitative Real-time PCR assays were performed to analyze the expression of miR-765 in human ESCC tissues and adjacent esophageal tissues. The relationships between miR-765 expression levels and the clinical factors were investigated by x2-test. Kaplan-Meier analysis was performed to evaluate the overall survival (OS) and disease-free survival (DFS) of ESCC patients with a different expression level of miR-765. The Cox proportional hazards regression model was used to assess the independent prognostic factors.

RESULTS

The expression level of miR-765 in ESCC tissues was significantly higher than that in their corresponding normal tissues (p < 0.01). High miR-765 expression was significantly correlated with tumor stage (p = 0.001), lymph nodes metastasis (p = 0.005), clinical stage (p = 0.007). In addition, Kaplan-Meier analysis showed that patients with higher miR-765 expression had a significantly poorer OS (p = 0.0010) and DFS (p< 0.0001) than those with lower miR-765 expression. Multivariate analyses revealed that miR-765 expression served as an independent predictor for both OS (p = 0.001) and DFS (p = 0.001).

CONCLUSIONS

Our findings provided the first evidence that miR-765 may serve as an indicator for prognosis of ESCC.

摘要

目的

先前的研究报道食管鳞癌（ESCC）中 miR-765 的表达上调。本研究旨在测量 ESCC 中 miR-765 的表达水平，并评估其在 ESCC 患者中的临床意义。

患者和方法

采用定量实时 PCR 检测分析人 ESCC 组织和相邻食管组织中 miR-765 的表达。x2 检验分析 miR-765 表达水平与临床因素的关系。Kaplan-Meier 分析评估 miR-765 不同表达水平的 ESCC 患者的总生存期（OS）和无病生存期（DFS）。Cox 比例风险回归模型评估独立的预后因素。

结果

ESCC 组织中 miR-765 的表达水平明显高于相应的正常组织（p < 0.01）。高 miR-765 表达与肿瘤分期（p = 0.001）、淋巴结转移（p = 0.005）、临床分期（p = 0.007）显著相关。此外，Kaplan-Meier 分析显示，miR-765 高表达患者的 OS（p = 0.0010）和 DFS（p< 0.0001）明显低于 miR-765 低表达患者。多变量分析显示，miR-765 表达是 OS（p = 0.001）和 DFS（p = 0.001）的独立预测因素。