Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine, Aurora, Colorado, United States of America.
Rocky Mountain Regional Spinal Injury System, Craig Rehabilitation Hospital, Englewood, Colorado, United States of America.
PLoS One. 2018 Jun 27;13(6):e0198969. doi: 10.1371/journal.pone.0198969. eCollection 2018.
Leptin is an adipo-myokine that regulates appetite and energy expenditure by a neuroendocrine feedback loop. Leptin levels are positively correlated with BMI in the spinal cord injury population and leptin levels are greater in individuals with spinal cord injury compared to uninjured controls. Leptin is produced in multiple tissues, including fat, bone, and skeletal muscle and is a putative biomarker of sedentary behavior in older adults. We assessed body composition leptin, adiponectin, and IL-6 levels in 205 men with chronic spinal cord injury. We found no association between age, injury duration, injury level, injury completeness, or walking status and leptin. There was a significant positive association between lean mass and leptin in men with SCI that was independent of fat. Adjusting for body composition, leptin levels were positively associated with IL-6 and negatively associated with adiponectin levels. When considering men with SCI and sarcopenic obesity, only fat mass remained positively associated with leptin. We found no association between IL-6, adiponectin, or lean mass and leptin in the sarcopenic obesity group. Our findings suggest that lean mass is an under recognized, but substantial, source of circulating leptin. Furthermore, SCI-related sarcopenic obesity may result in dysregulated adipo-myokine metabolism with local and systemic physiologic effects.
瘦素是一种脂肪-肌因子，通过神经内分泌反馈环调节食欲和能量消耗。在脊髓损伤人群中，瘦素水平与 BMI 呈正相关，与未受伤的对照组相比，脊髓损伤个体的瘦素水平更高。瘦素在多种组织中产生，包括脂肪、骨骼和骨骼肌，并且是老年人久坐行为的潜在生物标志物。我们评估了 205 名慢性脊髓损伤男性的身体成分、瘦素、脂联素和 IL-6 水平。我们发现年龄、损伤持续时间、损伤水平、损伤完整性或行走状态与瘦素之间没有关联。在患有 SCI 的男性中，瘦素与瘦体重之间存在显著的正相关关系，与脂肪无关。调整身体成分后，瘦素水平与 IL-6 呈正相关，与脂联素水平呈负相关。在考虑患有 SCI 和肌肉减少性肥胖的男性时，只有脂肪量与瘦素呈正相关。我们在肌肉减少性肥胖组中未发现 IL-6、脂联素或瘦体重与瘦素之间存在关联。我们的研究结果表明，瘦体重是循环瘦素的一个未被充分认识但很重要的来源。此外，与 SCI 相关的肌肉减少性肥胖可能导致脂肪-肌因子代谢失调，具有局部和全身生理效应。
