Pareja-Galeano Helios, Santos-Lozano Alejandro, Sanchis-Gomar Fabian, Fiuza-Luces Carmen, Garatachea Nuria, Gálvez Beatriz G, Lucia Alejandro, Emanuele Enzo
Universidad Europea de Madrid, Spain; Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain; GIDFYS, European University Miguel de Cervantes, Department of Health Sciences, Valladolid, Spain.
Mech Ageing Dev. 2017 Mar;162:129-132. doi: 10.1016/j.mad.2016.02.014. Epub 2016 Mar 2.
People reaching exceptional longevity free of major age-related diseases represent the paradigm of successful aging. Adipose tissue function declines as we age, potentially resulting in changes of circulating adipokines (e.g., leptin and adiponectin). Here, we measured circulating levels of leptin and adiponectin in healthy centenarians (n=81; 100-104 years) and younger elderly controls (n=46; 70-80 years). Centenarians had significant higher serum levels of leptin compared with controls (p<0.001), whereas no significant differences were observed for adiponectin. Further research including also other blood variables will be needed to elucidate whether high leptin levels could serve as a hallmark of healthy exceptional longevity.
无重大年龄相关疾病且寿命超长的人代表了成功衰老的范例。随着年龄增长，脂肪组织功能会下降，这可能导致循环脂肪因子（如瘦素和脂联素）发生变化。在此，我们测量了健康百岁老人（n = 81；年龄在100 - 104岁）和年轻老年对照组（n = 46；年龄在70 - 80岁）中瘦素和脂联素的循环水平。与对照组相比，百岁老人的血清瘦素水平显著更高（p < 0.001），而脂联素水平未观察到显著差异。需要进一步研究，包括其他血液变量，以阐明高瘦素水平是否可作为健康超长寿命的一个标志。
