Navarro-Tovar Gabriela, Rocha-García Denisse, Wong-Arce Alejandra, Palestino Gabriela, Rosales-Mendoza Sergio
Laboratorio de Biofarmacéuticos Recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava 6, San Luis Potosí 78210, Mexico.
Sección de Biotecnología, Centro de Investigación en Ciencias de la Salud y Biomedicina, Universidad Autónoma de San Luis Potosí, Av. Sierra Leona 550, Lomas 2ª. Sección, San Luis Potosí 78210, Mexico.
Materials (Basel). 2018 Jun 26;11(7):1083. doi: 10.3390/ma11071083.
Vaccinology faces the challenge of developing improved immunization approaches that are able to induce long-term immunity with the desired Th profile according to the pathology. In this context, new vehicles for efficient antigen delivery that exert adjuvant effects play a critical role in addressing this goal. Herein, mesoporous silicon particles (PSiP) were assessed as carriers for a peptide-based vaccine targeting the receptor for advanced glycation end products (RAGE), which is a relevant receptor in Alzheimer´s disease and other diseases. A RAGE peptide was adsorbed onto PSiP (PSiP vaccine) and administered to BALB/c mice, leading to immune responses that were similar in magnitude to those induced by the soluble peptide. However, the response induced by PSiP lasted for a significantly longer period when compared with the behavior of the group immunized with the peptide alone. Therefore, PSiP are proposed as carriers to enhance immune memory, which is critical in vaccination. This study opens interesting perspectives related to the application of PSiP in vaccinology.
疫苗学面临着开发改进的免疫方法的挑战，这些方法能够根据病理学诱导具有所需Th谱的长期免疫力。在这种情况下，发挥佐剂作用的新型高效抗原递送载体对于实现这一目标起着关键作用。在此，介孔硅颗粒（PSiP）被评估为一种基于肽的疫苗的载体，该疫苗靶向晚期糖基化终产物受体（RAGE），RAGE是阿尔茨海默病和其他疾病中的一种相关受体。将一种RAGE肽吸附到PSiP上（PSiP疫苗）并给予BALB/c小鼠，所引发的免疫反应在强度上与可溶性肽诱导的反应相似。然而，与单独用肽免疫的组相比，PSiP诱导的反应持续时间显著更长。因此，PSiP被提议作为增强免疫记忆的载体，这在疫苗接种中至关重要。这项研究为PSiP在疫苗学中的应用开辟了有趣的前景。
