Skoog L, Macias A, Azavedo E, Lombardero J, Klintenberg C
Br J Cancer. 1986 Aug;54(2):271-6. doi: 10.1038/bjc.1986.173.
The cellular content of receptors for epidermal growth factor (EGF) was measured in different histological subgroups of human mammary carcinomas. EGF receptors were detected in 36% of the ductal and all the medullary carcinomas. In contrast lobular and pure colloid tumours did not contain measurable amounts of the receptor. The receptor was found both among tumours with an euploid and aneuploid DNA pattern. The EGF receptor is thus found in carcinomas with a varying degree of differentiation as judged by the cellular DNA pattern. There was no correlation between the proliferative activity of the tumours as measured by thymidinekinase activity and the amount of EGF receptors in the tumour. Tumours with detectable EGF receptor often had low levels of oestrogen receptor. This finding could only partly be explained by the menstrual status of the patients.
在人类乳腺癌的不同组织学亚组中，对表皮生长因子（EGF）受体的细胞含量进行了测定。在36%的导管癌和所有髓样癌中检测到了EGF受体。相比之下，小叶癌和纯黏液性肿瘤未含有可测量的该受体。在具有整倍体和非整倍体DNA模式的肿瘤中均发现了该受体。因此，根据细胞DNA模式判断，在不同分化程度的癌中均发现了EGF受体。通过胸苷激酶活性测定的肿瘤增殖活性与肿瘤中EGF受体的含量之间无相关性。可检测到EGF受体的肿瘤通常雌激素受体水平较低。这一发现仅能部分由患者的月经状态来解释。
